Bioparticles Analysis and Characterization

• Protein Binding Affinity Analysis on Artificial Lipid Droplets
• Animal Models Evaluation
• Animal Model Construction
• mRNA-LNP Vaccine Laboratory Process Development Assay
• Bioimaging Services for Nanoparticles
• In Vivo Fates Prediction Study
• Bioparticles Zeta Potential Analysis
• Toxicity Measurement
• Bioparticles Stability Studies
• Pharmacodynamics and Pharmacokinetics Test
• Bioparticles Penetration and Permeation Test
• Lamellarity Determination
• Bioparticles Encapsulation Efficiency Analysis
• Drug Localization Analysis
• Drug In Vitro Testing
• Bioparticle Size and Morphology Analysis
• Bioparticle Component Analysis

CD Bioparticles’ services of wide coverage of Bioparticles Analysis and Characterization, and advanced metrology platforms can help you to solve:

The challenges you might meet:

• High complexity of the drug delivery bioparticle forms including dispersions, powders, and microcapsules requiring several methods for analysis and characterizations
• Lack of experiences of drug delivery system so that having no idea which technique to use
• Low quality and low accuracy of results
• Concerns about less-than-optimal techniques only available in-house

Figure 1. Analysis and characterization services for different nanoparticle parameters.

Bioparticles analysis and characterization key features:

• Toxicity Measurement

  • In Vitro Assessment Assays

    • DNA synthesis
    • DNA damage
    • Altered gene expression
    • Immunogenicity
    • Oxidative stress
    • Cell proliferation
    • Exocytosis
    • Metabolic activity
    • Hemolysis
    • Apoptosis and necrosis

  • In Vitro Assessment Assays

• Drug In Vitro Testing

  • In vitro drug release

  • In Vitro Toxicity Test

  • In Vitro Drug Sensitivity Tests

• Lamellarity Determination

  • ³¹P- nuclear Magnetic Resonance (NMR)

  • Small Angle X-ray Scattering (SAXS)

  • Cryo-electron Microscopy

• Drug Localization Analysis

  • Plasma Protein Binding

  • Brain Tissue Binding

  • Microsomal Binding

• Bioparticles Stability Studies

  • Analysis of Bioparticle Size and Morphology

  • Self-association (Agglomeration/Aggregation) Analysis

  • Analysis of Surface Charge Change

  • Analysis of Changes in Dissolution/Release Rate of Active Ingredients

• Bioparticle Component Analysis

  • X-ray Diffraction (XRD)

  • Liquid Chromatography-mass Spectrometry (LC-MS/MS)

  • Raman Spectroscopy

• Bioparticles Zeta Potential Analysis

• Bioparticle Size and Morphology Analysis

  • Dynamic Light Scattering (DLS)

  • Scanning Electron Microscopy (SEM)

  • Transmission Electron Microscope (TEM)

  • Atomic Force Microscopy (AFM)

• Pharmacodynamics and Pharmacokinetics Test

  • Microscale Thermophoresis

  • Mass Spectrometry

• Bioparticles Penetration and Permeation Test

  • Dermal Absorption Test

  • Parallel Artificial Membrane Permeability Assay (PAMPA)

  • Caco-2 Permeability

• Bioparticles Encapsulation Efficiency Analysis

Bioparticles analysis and characterization key benefits:

• Bulk Analysis and Characterization services including descriptive data analysis
• Our long-term experience and advanced metrology platforms can help you determine and optimize the most applicable technique, or the combination of techniques to solve your problem
• We can help you to optimize an experiment based on the most cost-effective strategies and provide you the deep data analysis based on descriptive and inferential statistics. . We will help you to know your materials better and provide you the solutions to solve your problems from every aspect.
• The quality and accuracy of analysis results are taken seriously. The design of experiments follows the principles of statistics
• Quick turnaround time
• No concerns about the scale of analysis. Analysis ranging from one-sample request to large-scope or multiple runs are all acceptable
• We offer customized analysis strategies and protocols development

If you don't see what you need, or don't know what you need, give us a call at 1-631-624-4882 or email, and our team will work with you to find the right solution for your analysis.