Beta cyclodextrins (β-CDs) have emerged as promising carriers in the field of drug delivery, owing to their unique molecular structure and versatile applications. These cyclic oligosaccharides consist of seven glucose units linked together in a torus-shaped ring, forming a hydrophobic cavity and a hydrophilic outer surface. This molecular arrangement enables β-CDs to encapsulate various guest molecules within their cavity through host-guest interactions, thereby improving the solubility, stability, and bioavailability of poorly soluble drugs.
The β-CD series offers several advantages in drug delivery, including enhanced drug solubility, protection of drugs from degradation, and targeted delivery to specific tissues or cells. Additionally, β-CDs are biocompatible and non-toxic, making them suitable for pharmaceutical applications. Furthermore, the ability of β-CDs to form inclusion complexes with a wide range of drug molecules, including hydrophobic, hydrophilic, and amphiphilic compounds, makes them highly versatile in drug formulation.
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