Block Copolymer Micelles

CD Bioparticles' products with customized delivery strategies, precise designs and modifications of drugs or drug-contained cargos, and advanced technical platforms can help you to solve:

The challenges you might meet:

• Limited drug-loading efficiency and yield
• Unpredictable or uncontrollable degradation rate of the drug-loading cargo
• Uncontrollable drug delivery profile
• Lack of cell-specific or tissue-specific targeting for nanomedicines
• Lack of functional groups for further modification/conjugation/crosslinking
• Tedious chemical synthesis and purifications

Block Copolymer Micelles Key Features

• Triblock Copolymers
  • PEO-PPO-PEO and derivatives
  • PLGA-PEG-PLGA and derivatives: degradable
  • PCL-PEG-PCL and derivatives: degradable
  • PEI-PEG-PEI and derivatives: cationic
  • P(D,L)LA-PEG-P(D,L)LA and derivatives: degradable
  • P(L)LA-PEG-P(L)LA and derivatives: degradable
  • pGlu-PEG-pGlu and derivatives: ionic
  • pAsp-PEG-pAsp and derivatives: cationic
• AB Diblock Copolymers
  • PLGA-PEG and derivatives
  • PCL-PEG and derivatives
  • P(D,L)LA-PEG and derivatives
  • PEI-PEG and derivatives
  • mPEG-PGlu and derivatives
  • Poly(L-Ornithine)-mPEG and derivatives
• Reactive group modification
  • Amine active: -NHS
  • Carboxylate active: -(Di)hydrazide
  • Thiol active: -Maleimide, -Iodolacetyl (IA), -Pyridyl disulfides, -SH,
  • Click reaction active: -Azide, -Dibenzocycolctyne (DBCO), -Alkyne, -Methyltetrazine
  • Biotin modified
  • Folate modified
  • Redox active
  • Radical reaction active: -Acrylate, -Methacrylate, -Vinylsulfone

Block Copolymer Micelles Key Benefits:

• A series of block copolymer for functional micelles fabrications
• Degradable block copolymer with controllable degradation rate for sustainable release
• Block copolymer assembled nanoparticles with controllable size and controllable core-shell ratio
• Controllable nanostructure for the assembly
• End-group functionalized block copolymers, useful for crosslinking and conjugation
• Sol-gel transition with controllable transition temperature for the tri-block copolymers
• Various of PEGylated hydrophobic polymer chain useful for forming "stealth" pegylated microparticles/nanoparticles
• Cationic copolymers useful for gene delivery

Block Copolymer Micelles Application Candidates:

• Biocompatible and biodegradable nanomaterials and bulk material fabrications
• Drug-delivery cargos with controllable delivery profile
• Hydrogels with sol-gel transition useful for reversible encapsulation and delivery
• Active materials with various of ready-to-use bio-conjugation options
• Functional materials with precisely controlled nano-domains