Dde Cleavable Linkers

Dde Cleavable Linkers can be used to introduce biotin components into biomolecules containing alkynes using click chemistry. Hydrophilic spacer arms improve the solubility of labeled molecules in hydrophilic media. The Dde protective group allows the use of hydrazine under mild conditions to release captured biotinized molecules from Streptomyces antibiotin proteins or antibiotin proteins. Due to their rupture resistance and specific cracking conditions, many Dde-based linkers have been developed for a variety of applications, including SPPS, oligosaccharide synthesis, etc.