What is a Nanocarrier* System?
| Nanocarrier Type | Characteristics | Size Range (nm) | Biocompatibility | Stability | Targeting | Main Application Range |
|---|---|---|---|---|---|---|
| Liposomes | Composed of phospholipid bilayer, good biocompatibility | 50-1000 | Good | Average stability in physiological environment, easily oxidized | Surface modification for passive or active targeting | Drug delivery, gene therapy, vaccine delivery |
| Polymer nanoparticles | Made of synthetic polymers, high stability, adjustable | 10-500 | Average, depends on polymer type | High, stability can be improved by modification | Surface modification for passive or active targeting | Drug delivery, gene therapy, imaging diagnosis |
| Peptide-based drug delivery systems | Composed of amino acids, high specificity | 1-10 | Good | Poor stability in physiological environment, easily degraded by enzymes | High, specific targeting can be achieved through peptide sequence design | Drug delivery, tumor therapy |
| Viral vector-based delivery systems | Using the infection characteristics of viruses, high efficiency | 20-300 | Average, strong immunogenicity | Stable in vitro, easily neutralized in vivo | Virus capsid has natural targeting | Gene therapy |
| Exosomes | Vesicles secreted by cells, good biocompatibility, not easily cleared by the immune system | 30-150 | Good | Good stability in physiological environment | Naturally targeted, can be further modified to enhance targeting | Drug delivery, disease diagnosis, regenerative medicine |
| Porous organic frameworks (POFs) | Porous structure, large specific surface area, can load a variety of molecules | 1-100 | Average, depends on material composition | High, stable chemical properties | Targeted delivery can be achieved through surface modification | Drug delivery, catalysis, separation |
| Protein-based nanoparticles | Self-assembled by protein molecules, good biocompatibility | 5-200 | Good | Poor stability in physiological environment, easily degraded by proteases | Targeting can be achieved through protein engineering | Drug delivery, vaccine delivery |
| Living cell-based drug delivery systems | Using living cells as carriers, with strong targeting | Tens of nanometers to tens of micrometers | Good | Stable in vitro, easily affected by the environment in vivo | Naturally targeted | Tumor therapy |
| Metal nanoparticles | Made of metal materials, with unique optical and electrical properties | 1-100 | Average, high toxicity | High, stable chemical properties | Targeted delivery can be achieved through surface modification | Imaging diagnosis, drug delivery, antibacterial |
| Nanocages | Nanoscale cage structure composed of multiple components | 2-100 | Average, depends on material composition | High, stable structure | Targeted delivery can be achieved through pore regulation | Drug delivery, catalysis, separation |
Advantages of Customized Nanoparticle Formulation
Wide Range of Applications*
Wide coverage of the biocompatible drug-delivery system for different dosage forms for different administration routes, such as oral formulation, injection formulation, cutaneous formulation, mucosal formulation, and inhalation formulation.
Simplified and Efficient Loading
Drug delivery systems simplify your drug delivery process and increase API drug delivery yield in a controlled manner.
Flexible Customization
Adaptable building blocks for customized formulation
One-stop Service
Analytical platforms cover from drug-delivery system fabrications to in-vitro and in-vivo tests
Drug-Oriented Design
Drug-oriented, customized drug-delivery system production and formulation improves the delivery efficiency of the drugs, such as small molecules, nucleic acids, or peptides
Optimizing Drug Properties
Improving the drug/API absorption/penetration/targeting, as well as the stability
High Quality Assurance
From pre-formulation to GMP process, promising the quality of products
Ready-to-use Drug-Delivery Systems
* More information on drug delivery via nanoparticle systems.
Drug Delivery Nanoparticle Customization Process
- 1
Project Initiation and Consultation
We begin by understanding your specific project needs through a detailed consultation with our clients. This ensures that our services meet your goals and requirements.
- 2
Customized Service Plans
Based on your needs, we will provide a detailed proposal outlining the scope of work, methods, timeline and costs.
- 3
Load Management
You can provide the load directly or have us purchase it on your behalf. If you choose to provide, a specific MSDS and COA are required to ensure safe and compliant shipping. Once the load is received, we will confirm the integrity of the load before further processing.
- 4
Expert Design and Quality Control
Our team uses state-of-the-art technology and instrumentation for the design, characterization, encapsulation and subsequent testing of nanoparticle systems. Strict quality control measures are applied at each stage to ensure reliable and accurate results.
- 5
Results and Reporting
Upon completion, we will provide a drug-loaded nanoparticle system that can be used directly in subsequent development and a comprehensive report that includes detailed nanoparticle system parameters, expert analysis and actionable insights. We ensure that the report meets your expectations and regulatory needs before finalization.
- 6
Ongoing Expertise and Support
Even after the project ends, we remain committed to your success and provide ongoing support for any further analysis or adjustments required as the project evolves.
Instrument Platform
CD Bioparicles is equipped with a complete set of advanced nanoparticle carrier synthesis platforms, including high shear mixers, ultrasonic crushers, spray dryers, rotary evaporators, emulsifiers and other high-end instruments for the synthesis of nanoparticle systems. These tools enable the synthesis of nanoparticles with accurate size and homogeneity. In addition, our capabilities also extend to the use of TEM, SEM, XRD and DLS, particle size analyzers to detect and characterize nanoparticles.
Nanoparticles Formulation Application Candidates
- Nanoparticles with low targeting efficiency and low targeting specificity
- Cell specific, or tissue specific targeted delivery
- For more on organ-targeted drug delivery systems, click on here.
- Non-invasive therapy or minimally invasive therapy
- Programmable delivery
- Drugs/API delivery with different administration routes
More information on the applications of nanoparticle systems.
How do I choose the best nanoparticle carrier for my drug?
We have a complete range of nanoparticle carriers and can tailor the optimal solution based on your drug properties and treatment goals. We have rich experience and advanced synthesis technology to provide you with high-quality and efficient nanocarriers, which can significantly improve the bioavailability and targeting of drugs, thereby improving the therapeutic effect.
I am worried about the product quality and delivery time of customized services.
We fully understand the importance of the quality and cycle of customized services to our customers. We have an experienced scientific research team, produce in strict accordance with GMP standards, and provide comprehensive quality inspection reports. At the same time, we have established an efficient production process to deliver customized products to you in the shortest possible time. In addition, we also provide one-on-one project management services to answer your questions at any time to ensure the smooth progress of the project.
What are the differences between different types of nanoparticles? How should I choose?
Different types of nanoparticles have different properties and applicability. Our technical team can provide you with a detailed introduction to the advantages and disadvantages of various nanoparticles based on your specific needs and help you choose the most suitable carrier. For example, liposomes have good biocompatibility, polymer nanoparticles have high drug loading capacity, and inorganic nanoparticles have good stability.
I need professional technical guidance to help me complete this project.
We provide you with a full range of technical support services, including:
- Formulation design: Assist you in designing the best nanoparticle formulation based on your drug characteristics.
- Process optimization: Improve product quality and yield by optimizing the synthesis process.
- Characterization analysis: Provide comprehensive product characterization analysis to ensure that the product meets your requirements.
- Technical consulting: During the entire cooperation process, we will provide you with professional technical consulting services.
