Storage | Should always be stored at in the dark at 4 °C, except when brought to room temperature for brief periods prior to animal dosing. DO NOT FREEZE. If the suspension is frozen, the encapsulated drug can be released from the liposomes thus limiting its effectiveness. In addition, that the size of the liposomes will also change upon freezing and thawing. |
Description | Cardiolipin (CL) is a unique phospholipid with a very interesting chemical and specific ultrastructural characteristics. It is a highly acid dimer of phosphatidylglycerol (PG) and phosphatidic acid (PA), containing four acyl chains; three glycerols and two phosphate headgroups. Due to deprotonation of one of one of these phosphate groups, cardiolipin is negatively charged in physiological pH. Cardiolipin (CL) is known as mitochondria-specific phospholipid since it is almost exclusively biosynthesized and located in the inner mitochondrial membranes. The name “cardiolipin” is derived from fact …More > |
Lipid composition | PC/CL (0.5/99.5 molar ratio) |
Liposome Size | 1-2 μm |
Lipid Molar Concentration | 10 mM |
Buffer | Phosphate Buffered Saline, pH 7.4 |
Shelf-life | 4 months. |
Technical Notes | Liposomes are multilamellar structure. Liposomes are made in PBS buffer at pH 7.4 but it can be made in any other buffer of your choice. You can specify your buffer at the time of ordering. Liposomes are made in degassed buffer that is purged with argon to avoid oxidation of the unsaturated phospholipids. Liposomes are made under sterile condition. Liposomes are unilamellar and therefore due to their small size they will not settle in the bottom of the vial. If you need to take multiple aliquots out of the vial during a period of time, then it is advised to take extreme care in not contaminati…More > |
Product Name | Catalog | Lipid composition | Liposome Size | Price |
---|---|---|---|---|
Clipos™ Cardiolipin Lipids (CL) Liposomes | CDECAR-1683 | PC/CL (90/10 molar ratio) | 1-2 μm | $2100 |
Clipos™ Cardiolipin Lipids (CL) Liposomes | CDECAR-1689 | PC/CL (40/60 molar ratio) | 1-2 μm | $2100 |
Clipos™ Cardiolipin Lipids (CL) Liposomes | CDECAR-1661 | PC/CL (1/99 molar ratio) | 50 nm | $2100 |
Clipos™ Cardiolipin Lipids (CL) Liposomes | CDECAR-1657 | PC/CL (20/80 molar ratio) | 50 nm | $2100 |
Clipos™ Cardiolipin Lipids (CL) Liposomes | CDECAR-1682 | 100% 14/0 Cardiolipin (TMCL) | 1-2 μm | $2100 |
Clipos™ Cardiolipin Lipids (CL) Liposomes | CDECAR-1643 | PC/CL (2/98 molar ratio) | 100 nm | $2100 |
Clipos™ Cardiolipin Lipids (CL) Liposomes | CDECAR-1648 | 100% 14/0 Cardiolipin (TMCL) | 50 nm | $2100 |
Clipos™ Cardiolipin Lipids (CL) Liposomes | CDECAR-1647 | 100% 18/1 Cardiolipin (TOCL) | 50 nm | $2100 |
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