Blue dextran is a nanocarrier in the field of drug delivery systems. As a high molecular weight polysaccharide, Dextran’s good biocompatibility, water solubility, and ability to form stable conjugates make it an ideal choice for various drug delivery systems. The addition of the Cibacron blue F3GA group not only enhances their visibility and traceability in biological systems but also facilitates their application in many diagnostic and therapeutic applications. Although the addition of blue groups is beneficial for drug tracing in vivo, the key to improving drug delivery mechanism lies in its main molecule - dextran. The study found that the main advantage of the drug carrier system composed of Blue Dextran in drug delivery lies in its molecular structure, which can effectively encapsulate and control the release of therapeutic agents. By forming a stable delivery system with drugs, Blue Dextran can significantly improve the bioavailability and stability of the drugs it loads. This polysaccharide acts as a protective matrix, preventing premature degradation of the active pharmaceutical ingredient and ensuring targeted release at the site of action. This targeted approach not only maximizes therapeutic efficacy but also minimizes potential side effects, presenting a superior alternative to conventional drug delivery methods. Additionally, the blue dye component of blue dextran offers unique advantages in monitoring and tracking drug distribution within biological systems. This chromophore provides a visual marker that can be easily detected using a variety of imaging techniques, allowing researchers and clinicians to precisely map the pharmacokinetics and biodistribution of drug-carrier complexes. This capability is especially valuable in preclinical and clinical research, where understanding the behavior of drug delivery systems in vivo is critical to optimizing dosing regimens and improving patient outcomes. The combination of diagnostic and therapeutic functions in a single delivery system demonstrates the potential of the delivery system constituted by Blue Dextran, which warrants further exploration in its research and application.
Figure 1. Dextran is involved in the manufacture of tumor microenvironment-sensitive drug release carriers. (Hao Wang, et al.; 2017)
The biocompatibility of blue dextran is one of its most attractive properties, as it ensures that the drug carrier system produces minimal immunogenic response when injected into the body. Unlike some synthetic polymers that may trigger adverse immune responses, blue glucan is generally well tolerated by the human body because it is derived from nature products. Studies have shown that in addition to Blue Dextran’s biocompatibility, its water solubility plays an important role in its functionality as a drug carrier. The hydrophilicity of dextran makes it easily soluble in biological fluids, so the delivery system it participates in can help the loaded poorly soluble drugs dissolve in the aqueous environment in the body. This is beneficial to the administration of drugs and their distribution throughout the body. This property is particularly beneficial for intravenous drug delivery, where rapid and uniform dispersion of therapeutic agents is critical for effective treatment. Furthermore, the water-soluble nature of Blue Dextran aids in its excretion from the body, reducing the likelihood of accumulation and potential toxicity. The stability of Blue Dextran-drug complexes is another factor that enhances their effectiveness in drug delivery. The stability of these drug and nanocarrier systems ensures the integrity and activity of the therapeutic drugs until they reach their intended target. This stability is particularly important for drugs that are prone to degradation under harsh conditions in the gastrointestinal tract or circulatory system. By preventing premature breakdown of loaded drugs, nanosystems composed of Blue Dextran help maintain their therapeutic potency, thereby achieving the desired effect at lower dosages. This not only improves patient compliance but also reduces the overall cost of treatment.
Blue Dextran's uses go beyond being a drug carrier. It can also be used in a variety of diagnostic applications, taking full advantage of its visibility and traceability. In these applications, its blue color contrasts with the natural color of biological tissue, allowing for precise imaging and analysis. This dual function as both a therapeutic vehicle and a diagnostic agent highlights the diverse uses of blue dextran in medicine. Research into blue glucan is still ongoing, and scientists continue to explore new ways to enhance its effectiveness and broaden its applications. Innovations in various drug delivery technologies, such as the development of composite delivery systems such as nanoparticles and liposomes, have opened up new avenues for the use of blue dextran. By incorporating it into these advanced delivery systems, researchers aim to further improve the targeting and release properties of drugs. In addition, the researchers expanded the potential applications of blue dextran by changing its molecular structure to enhance its binding affinity and stability.
Alternate Names:
Dextran blue
Dextran labeled with blue dye
Blue dextran 2000
Dextran-Blue conjugate
References:
1. Hao Wang, et al.; Self-Assembly Assisted Fabrication of Dextran-Based Nanohydrogels with Reduction-Cleavable Junctions for Applications as Efficient Drug Delivery Systems. Scientific Reports. 2017, volume 7, 40011.
Q & A
Q: Do you have any idear about their solubility?
A: Blue Dextran will be soluble when heated to 80 °C during continuous stirring.
Q: What are the storage conditions for the product?
A: The shipping condition for the product is room temperature.
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Fast-responsive porous thermoresponsive microspheres for controlled delivery of macromolecules
Int J Pharm.
Authors: Fundueanu G, Constantin M, Ascenzi P.
Abstract
Porous thermoresponsive microspheres with a homogeneous dimension and distribution of the pores are synthesized by an original method. Poly(N-isopropylacrylamide-co-acrylamide) (poly(NIPAAm-co-AAm)) copolymer was obtained as a thermoresponsive material with a lower critical solution temperature (LCST) under physiologic-like conditions (i.e., at 37 degrees C and pH 7.4, 50mM phosphate buffer). Semitelechelic oligomers of NIPAAm (ONIPAAm) were also synthesized in the presence of 3-mercaptopropionic acid (MPA) (chain transfer molecule) which acts as a pore-forming agent. Poly(NIPAAm-co-AAm) and ONIPAAm were solubilized in acidified aqueous solution, dispersed in a mineral oil, and transformed in stable microspheres by crosslinking the amide group with glutaraldehyde at temperatures below and above the LCST of the oligomers, and always below the LCST of the polymer. Microspheres obtained at temperatures below the LCST of ONIPAAm are characterized by a homogeneous porous structure with a narrow distribution of the pore size. These microspheres are characterized by a very rapid response rate when the temperature changes below and above the body temperature. The higher is the amount of the porogen in the polymer solution, the larger is the pore size and faster is the response rate. The porous microspheres with suitable pore size are a conveyable matrix for loading and temperature-controlled release of the high molecular weight model drug blue dextran (BD).
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