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DBCO-PEG4-acetic-Val-Cit-PAB


DBCO-PEG4-acetic-Val-Cit-PAB

Catalog:CDAX091

Unit Size
Price
$1680

Buy Now Datasheet

Common UseDBCO-PEG4-acetic-Val-Cit-PAB-OH is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADC). The Val-Cit is specifically cleaved by cathepsin B. As this enzyme is only present in the lysosome the ADC payload will be release only in the cell. The Boc group can be deprotected under acidic conditions to generate a free amine group.
Structure DBCO-PEG4-acetic-Val-Cit-PAB
Purity≥95%
Molecular Weight855.99
Molecular FormulaC45H57N7O10

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