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Clipos™ Phosphatidylcholine (PC) Liposomes, PEGylated


Catalog:CDEPG-38

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INQUIRY Datasheet

Storage2 °C to 8 °C (do not freeze)
DescriptionLong-circulating, PEGylated drug composite liposomes containing daunorubicin HCl and vincristine sulfate at a 10/1 (mol/mol) ratio. The liposomes are loaded by an ammonium sulfate gradient method, sterilized by submicron filtration, and dispensed aseptically into sterile glass vials. The liposomes are useful for the study of ratiometric dosing with chemotherapeutic agents in preclinical models of cancer, suitable for use in vitro or in vivo.
Lipid compositionHSPC/Chol/DSPE-mPEG2000 (56.2/38.5/5.3 molar ratio)
Liposome Size80-120 nm
Lipid Molar Concentration30 mM
Shelf-life6 months
Encapsulated DrugDaunorubicin, Vincristine
Drug concentration1.4 mg/mL, 219 μg/mL
Inside Buffer250 mM Ammonium Sulfate, pH 5.5
Outside Buffer154 mM NaCl, pH 5.5
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