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Quizartinib


Quizartinib

Catalog:CDMDC03

INQUIRY Datasheet

SynonymAC220
Common UseQuizartinib (AC220) is an orally active, highly selective and potent second-generation type II FLT3 tyrosine kinase inhibitor, with a Kd of 1.6 nM. Quizartinib inhibits wild-type FLT3 and FLT3-ITD autophosphorylation in MV4-11 cells with IC50s of 4.2 and 1.1 nM, respectively. Quizartinib can be linked to the VHL ligand via an optimized linker to form a PROTAC FLT3 degrader. Quizartinib induces apoptosis.
Structure Quizartinib
Purity0.9887
Storage• Powder: -20°C 3 years; 4°C 2 years • In solvent: -80°C 6 months; -20°C 1 month
Molecular Weight560.67
Molecular FormulaC29H32N6O4S
CAS No.950769-58-1
AppearanceSolid
SolubilityDMSO: 150 mg/mL (179.47 mM)
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