Synonym | AC220 |
Common Use | Quizartinib (AC220) is an orally active, highly selective and potent second-generation type II FLT3 tyrosine kinase inhibitor, with a Kd of 1.6 nM. Quizartinib inhibits wild-type FLT3 and FLT3-ITD autophosphorylation in MV4-11 cells with IC50s of 4.2 and 1.1 nM, respectively. Quizartinib can be linked to the VHL ligand via an optimized linker to form a PROTAC FLT3 degrader. Quizartinib induces apoptosis. |
Structure | |
Purity | 0.9887 |
Storage | • Powder: -20°C 3 years; 4°C 2 years • In solvent: -80°C 6 months; -20°C 1 month |
Molecular Weight | 560.67 |
Molecular Formula | C29H32N6O4S |
CAS No. | 950769-58-1 |
Appearance | Solid |
Solubility | DMSO: 150 mg/mL (179.47 mM) |
Catalog: CDMDC64
Catalog: CDMDC46
Catalog: CDMDC15
Catalog: CDMDC09
Catalog: CDMDC44
Catalog: CDMDC47
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Catalog: CDMDC71
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