Common Use | N-piperidine Ibrutinib hydrochloride (Compound 1) is a reversible Ibrutinib derivative. N-piperidine Ibrutinib hydrochloride is a potent BTK inhibitor with IC50s of 51.0 and 30.7 nM for WT BTK and C481S BTK, respectively. N-piperidine Ibrutinib hydrochloride can be used as a BTK ligand in the synthesis of a series of PROTACs, such as SJF620 (HY-133137). SJF620 is a potent PROTAC BTK degrader with a DC50 of 7.9 nM. |
Structure | |
Purity | 0.953 |
Storage | • -20°C, sealed storage, away from moisture and light • In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light) |
Molecular Weight | 422.91 |
Molecular Formula | C22H23ClN6O |
CAS No. | 2231747-18-3 |
Appearance | Solid |
Solubility | • DMSO: 100 mg/mL (236.46 mM) • H2O: 50 mg/mL (118.23 mM) |
Catalog: CDMDC22
Catalog: CDMDC28
Catalog: CDMDC43
Catalog: CDMDC06
Catalog: CDMDC40
Catalog: CDMDC46
Catalog: CDMDC33
Catalog: CDMDC54
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