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N-piperidine Ibrutinib hydrochloride


N-piperidine Ibrutinib hydrochloride

Catalog:CDMDC18

INQUIRY Datasheet

Common UseN-piperidine Ibrutinib hydrochloride (Compound 1) is a reversible Ibrutinib derivative. N-piperidine Ibrutinib hydrochloride is a potent BTK inhibitor with IC50s of 51.0 and 30.7 nM for WT BTK and C481S BTK, respectively. N-piperidine Ibrutinib hydrochloride can be used as a BTK ligand in the synthesis of a series of PROTACs, such as SJF620 (HY-133137). SJF620 is a potent PROTAC BTK degrader with a DC50 of 7.9 nM.
Structure N-piperidine Ibrutinib hydrochloride
Purity0.953
Storage• -20°C, sealed storage, away from moisture and light • In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
Molecular Weight422.91
Molecular FormulaC22H23ClN6O
CAS No.2231747-18-3
AppearanceSolid
Solubility• DMSO: 100 mg/mL (236.46 mM) • H2O: 50 mg/mL (118.23 mM)

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