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BMS-1166-N-piperidine-COOH


BMS-1166-N-piperidine-COOH

Catalog:CDMDC42

INQUIRY Datasheet

Common UseBMS-1166-N-piperidine-COOH, the BMS-1166-based moiety, binds to E3 ligase ligand via a linker to form PROTAC PD-1/PD-L1 degrader-1 (HY-131183) to degrade PD-1/PD-L1. BMS-1166 is a potent PD-1/PD-L1 interaction inhibitor with an IC50 of 1.4 nM. BMS-1166 antagonizes the inhibitory effect of PD-1/PD-L1 immune checkpoint on T cell activation.
Structure BMS-1166-N-piperidine-COOH
Purity0.9726
Storage• -20°C, sealed storage, away from moisture and light • In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
Molecular Weight639.14
Molecular FormulaC37H35ClN2O6
CAS No.2447066-00-2
AppearanceSolid
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