Common Use | BMS-1166-N-piperidine-COOH, the BMS-1166-based moiety, binds to E3 ligase ligand via a linker to form PROTAC PD-1/PD-L1 degrader-1 (HY-131183) to degrade PD-1/PD-L1. BMS-1166 is a potent PD-1/PD-L1 interaction inhibitor with an IC50 of 1.4 nM. BMS-1166 antagonizes the inhibitory effect of PD-1/PD-L1 immune checkpoint on T cell activation. |
Structure | |
Purity | 0.9726 |
Storage | • -20°C, sealed storage, away from moisture and light • In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light) |
Molecular Weight | 639.14 |
Molecular Formula | C37H35ClN2O6 |
CAS No. | 2447066-00-2 |
Appearance | Solid |
Catalog: CDMDC20
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Catalog: CDMDC41
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