Common Use | Spermine phosphoramidite is used to produce oligospermine-oligonucleotide conjugates - Zip Nucleic Acids Oligos. The conjugates are believed to use the oligospermine to seek out and move along (scan) oligonucleotide strands until the probe complementary sequence is located. The oligospermine then performs the function of stabilizing the formed duplex by reducing electrostatic repulsion, thereby leading to significantly increased binding affinities. Spermine phosphoramidite is simple to use in oligonucleotide synthesis and can be added multiple times at the 3' or 5' terminus. Deprotection and isolation are also straightforward. HPLC analysis of the conjugates requires high pH to suppress the ionization of the spermine residues. |
Structure | |
Storage | Freezer storage, -10 to -30°C, dry |
Molecular Weight | 1233.17 |
Molecular Formula | C56H73F12N6O9P |
Stability | 1-2 days |
Catalog: CDGLR01
Catalog: CDGLR08
Catalog: CDGLR04
Catalog: CDGLR02
Catalog: CDGLR05
Catalog: CDGLR03
Catalog: CDGLR06
Catalog: CDGLR07
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