Synonym | Tat-NR2Bct TFA, NA-1 TFA |
Common Use | Tat-NR2B9c TFA (Tat-NR2Bct TFA) is a postsynaptic density-95 (PSD-95) inhibitor, with EC50 values of 6.7 nM and 670 nM for PSD-95d2 (PSD-95 PDZ domain 2) and PSD-95d1, respectively. Tat-NR2B9c TFA disrupts the PSD-95/NMDAR interaction, inhibiting NR2A and NR2B binding to PSD-95 with IC50 values of 0.5 μM and 8 μM, respectively. Tat-NR2B9c TFA also inhibits neuronal nitric oxide synthase (nNOS)/PSD-95 interaction, and possesses neuroprotective efficacy |
Structure | |
Purity | ≥99% |
Storage | Powder: -80 °C, 2 years; -20 °C, 1 year. In solvent: -80 °C, 6 months; -20 °C, 1 month (sealed storage, away from moisture) |
Molecular Weight | 2632.9 |
Molecular Formula | C105H188N42O30.C2HF3O2 |
CAS No. | 1834571-04-8 |
Appearance | Solid |
Solubility | Soluble in water |
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