Synonym | Tat-NR2Bct, NA-1 |
Common Use | Tat-NR2B9c (Tat-NR2Bct; NA-1) is a postsynaptic density-95 (PSD-95) inhibitor, with EC50 values of 6.7 nM and 670 nM for PSD-95d2 (PSD-95 PDZ domain 2) and PSD-95d1, respectively. Tat-NR2B9c disrupts the PSD-95/NMDAR interaction, inhibiting NR2A and NR2B binding to PSD-95 with IC50 values of 0.5 μM and 8 μM, respectively. Tat-NR2B9c also inhibits neuronal nitric oxide synthase (nNOS)/PSD-95 interaction, and possesses neuroprotective efficacy |
Structure | |
Purity | ≥99% |
Storage | Powder: -80 °C, 2 years; -20 °C, 1 year. In solvent: -80 °C, 6 months; -20 °C, 1 month (sealed storage, away from moisture) |
Molecular Weight | 2518.88 |
Molecular Formula | C105H188N42O30 |
CAS No. | 500992-11-0 |
Appearance | Solid |
Solubility | Soluble in water |
Catalog: CDCCP23-091L
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