Common Use | Licochalcone B is an extract from the root of Glycyrrhiza uralensis. Licochalcone B inhibits amyloid β (42) self-aggregation (IC50=2.16 μM) and disaggregate pre-formed Aβ42 fibrils, reduce metal-induced Aβ42 aggregation through chelating metal ionsLicochalcone B inhibits phosphorylation of NF-κB p65 in LPS signaling pathway. Licochalcone B inhibits growth and induces apoptosis of NSCLC cells. Licochalcone B specifically inhibits the NLRP3 inflammasome by disrupting NEK7‐NLRP3 interaction |
Structure | |
Purity | ≥99% |
Storage | 4 °C, protect from light. In solvent : -80 °C, 6 months; -20 °C, 1 month (protect from light) |
Molecular Weight | 286.28 |
Molecular Formula | C16H14O5 |
CAS No. | 58749-23-8 |
Appearance | Solid |
Solubility | Soluble in DMSO |
Insoluble | Insoluble in H2O |
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