Common Use | 7,4'-Dihydroxyflavone (7,4'-DHF) is a flavonoid isolated from Glycyrrhiza uralensis, the eotaxin/CCL11 inhibitor, has the ability to consistently suppress eotaxin production and prevent dexamethasone (Dex)‐paradoxical adverse effects on eotaxin production[1]. 7,4'-Dihydroxyflavone (7,4'-DHF) inhibits MUC5AC gene expression, mucus production and secretion via regulation of NF-κB, STAT6 and HDAC2. 7,4'-Dihydroxyflavone (7,4'-DHF) decreases phorbol 12-myristate 13-acetate (PMA) stimulated NCI-H292 human airway epithelial cell MUC5AC gene expression and mucus production with IC50 value of 1.4 μM |
Structure | |
Purity | ≥99% |
Storage | Powder: -20 °C, 3 years; 4 °C, 2 year. In solvent: -80 °C, 2 years; -20 °C, 1 year |
Molecular Weight | 254.24 |
Molecular Formula | C15H10O4 |
CAS No. | 2196-14-7 |
Appearance | Solid |
Solubility | Soluble in DMSO |
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