Storage | Store at 4°C |
Description | CCL2 (Chemokine (C-C motif) ligand 2), commonly known as monocyte chemoattractant protein-1 (MCP-1), belongs to a family of secreted proteins involved in immune regulatory and inflammatory processes. Mature wild-type CCL2 protein has a full length of 76 amino acids, and its N-terminal residues are crucial in activating the CCL2 signaling pathway. The CCL2 mutant (9-76 amino acids), also known as 7ND, is a deletion of the first 8 residues of wild-type CCL2, which can bind to the C-C chemokine receptors CCR2 and CCR4 on the surface of monocytes, but cannot activate the down-regulated pathway. Therefore, the CCL2 mutant can be used as an inhibitory form of wild-type CCL2 to block the C-C chemokine receptors of CCL2 and inhibit unwanted monocyte/macrophage recruitment. This product is designed as a tool for the delivery and expression of the mature wild-type CCL2 mRNA for research. The product leverages the lipid nanoparticle (LNP) technology platform for simple and efficient delivery of CCL2 mRNA to a variety of mammalian cells in vitro and in vivo. The LNPs used are formulated with SM-102, DSPC, cholesterol and DMG-PEG2000 at an optimal molar concentration for a high rate of encapsulation and efficient mRNA delivery |
Lipid composition | SM-102/DSPC/Cholesterol/DMG-PEG2000 |
Technical Notes | Work with mRNA-LNP on ice. It is important to minimize the time that the product spends at room temperature; after handling product during experiments, return immediately to ice.Upon receiving product, briefly pulse spin before opening to ensure product is at bottom of container; it is important not to spin for too long as this may rupture mRNA-LNP’s. Do not vortex. mRNA-LNP products should only be handled with certified RNAase-free reagents and consumables; use of filtered pipette tips is highly recommended |
Encoding mRNA | CCL-2 |
In Vitro QC (Cell Types) | HEK293S |
Technology Applications | Protein research |
Product Name | Catalog | Lipid composition | Liposome Size | Price |
---|---|---|---|---|
Clipos™ CCL2 mRNA Lipid Nanoparticles | CDL23-088-L | SM-102/DSPC/Cholesterol/DMG-PEG2000 | $1980 | |
Clipos™ CCL2 mRNA Lipid Nanoparticles | CDL23-034-L | SM-102/DSPC/Cholesterol/DMG-PEG2000 | $1980 | |
Clipos™ CCL2 mRNA Lipid Nanoparticles | CDL23-015-L | SM-102/DSPC/Cholesterol/DMG-PEG2000 | $1595 | |
Clipos™ CCL2 mRNA Lipid Nanoparticles | CDL23-084-L | SM-102/DSPC/Cholesterol/DMG-PEG2000 | $1595 | |
Clipos™ CCL2 mRNA Lipid Nanoparticles | CDL23-027-L | SM-102/DSPC/Cholesterol/DMG-PEG2000 | $1980 | |
Clipos™ CCL2 mRNA Lipid Nanoparticles | CDL23-091-L | SM-102/DSPC/Cholesterol/DMG-PEG2000 | $1695 | |
Clipos™ CCL2 mRNA Lipid Nanoparticles | CDL23-080-L | SM-102/DSPC/Cholesterol/DMG-PEG2000 | $1595 | |
Clipos™ CCL2 mRNA Lipid Nanoparticles | CDL23-019-L | SM-102/DSPC/Cholesterol/DMG-PEG2000 | $1695 |
1. Download the template.
2. Enter product information on the template (maximum number of products: 200).
3. Load the file using selector below.
1. Download the template.
2. Enter product information on the template (maximum number of products: 200).
3. Load the file using selector below.