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Clipos™ Anti-CD147 CAR mRNA Lipid Nanoparticles

Catalog:CDL23-030-L

Unit Size
Price
$1980

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Specifications QA & Reviews
StorageStore at 4°C
DescriptionCD147 (cluster of differentiation 147) is a member of the immunoglobulin superfamily and is encoded by the BSG gene. This glycoprotein, originally known as a matrix metalloproteinase (MMP) modulator, was considered a potential target for cancer therapy. CD147 is overexpressed in cancer cells and promotes the malignant properties of cancer cells. Since CD147 is associated with certain monocarboxylate transporters, it is considered a key metabolic regulator in cancer. CD147 also regulates the angiogenic process by regulating the production of vascular endothelial growth factor (VEGF) in tumor and stromal cells. This product is designed as a tool for the delivery and expression of anti-CD147 CAR mRNA for research. The product leverages the lipid nanoparticle (LNP) technology platform for simple and efficient delivery of anti-CD147 CAR mRNA to a variety of mammalian cells in vitro and in vivo. The LNPs used are formulated with SM-102, DSPC, cholesterol and DMG-PEG2000 at an optimal molar concentration for a high rate of encapsulation and efficient mRNA delivery. The anti-CD147 CAR in this product is approximately 56 kD and consists of anti-CD147 scFv (single-chain variable fragment) linked to a second-generation CAR (chimeric antigen receptor) containing the CD8 hinge and transmembrane domain and 4-1BB and CD3ζ signaling domains
Lipid compositionSM-102/DSPC/Cholesterol/DMG-PEG2000
Technical NotesWork with mRNA-LNP on ice. It is important to minimize the time that the product spends at room temperature; after handling product during experiments, return immediately to ice.Upon receiving product, briefly pulse spin before opening to ensure product is at bottom of container; it is important not to spin for too long as this may rupture mRNA-LNP’s. Do not vortex. mRNA-LNP products should only be handled with certified RNAase-free reagents and consumables; use of filtered pipette tips is highly recommended
Encoding mRNABSG
In Vitro QC (Cell Types)HEK293S, T Cells
Technology ApplicationsCAR-T
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