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Clipos™ 4-1BBL mRNA Lipid Nanoparticles

Catalog:CDL23-039-L

Unit Size

200 μL

Price: $1595

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Specifications QA & Reviews

Storage	Store at 4°C
Description	4-1BB ligand (4-1BBL), also known as tumor necrosis factor ligand superfamily member 9 (TNFSF9) or CD137L, encoded by the TNFSF9 gene, is a type 2 trans Membrane glycoprotein receptor that binds 4-1BB (also known as CD137). This receptor promotes clonal expansion, survival and development of T cells by binding to its receptor 4-1BB. 4-1BBL can also induce peripheral monocyte proliferation, enhance TCR/CD3-triggered activation-induced T cell apoptosis, and modulate CD28 co-stimulation to promote Th1 cell responses. The interaction between 4-1BB and 4-1BBL provides co-stimulatory signals to a variety of T cells and is suggested for the development of cancer immunotherapies. This product is designed as a tool for the delivery and expression of human 4-1BBL mRNA for research. The product leverages the lipid nanoparticle (LNP) technology platform for simple and efficient delivery of 4-1BBL mRNA to a variety of mammalian cells in vitro and in vivo. The LNPs used are formulated with SM-102, DSPC, cholesterol and DMG-PEG2000 at an optimal molar concentration for a high rate of encapsulation and efficient mRNA delivery. The 4-1BBL protein is about 28 kD and consists of 254 amino acids
Lipid composition	SM-102/DSPC/Cholesterol/DMG-PEG2000
Technical Notes	Work with mRNA-LNP on ice. It is important to minimize the time that the product spends at room temperature; after handling product during experiments, return immediately to ice.Upon receiving product, briefly pulse spin before opening to ensure product is at bottom of container; it is important not to spin for too long as this may rupture mRNA-LNP’s. Do not vortex. mRNA-LNP products should only be handled with certified RNAase-free reagents and consumables; use of filtered pipette tips is highly recommended
Encoding mRNA	TNFSF9
In Vitro QC (Cell Types)	HEK293S
Technology Applications	Protein research

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