×
Shopping Cart
×
Quote List
0Quotes
0Cart

Clipos™ ICOSL-TF tag mRNA Lipid Nanoparticles

Catalog:CDL23-040-L

Unit Size
Price
$1595

Buy Now Need technical support? Datasheet

Specifications QA & Reviews
StorageStore at 4°C
DescriptionICOS ligand (ICOSL), also known as cluster of differentiation 275 or CD275, is a glycosylated transmembrane protein belonging to the B7 family, encoded by the ICOSLG gene. ICOSL is expressed on the surface of antigen-presenting cells and non-hematopoietic cells under inflammatory conditions. By binding to inducible T cell costimulator (ICOS), ICOSL triggers distinct intracellular signaling cascades and delivers costimulatory signals that promote T cell activation and differentiation. The ICOS/ICOSLG signaling pathway has been shown to promote antitumor T cell responses as it is activated in Th1 and other Teff cells, or promotes tumor responses when triggered in Tregs cells. Both agonistic and antagonistic monoclonal antibodies targeting this pathway may be used in cancer immunotherapy. This product is designed as a tool for the delivery and expression of TF-tagged human ICOSL mRNA for research. The product leverages the lipid nanoparticle (LNP) technology platform for simple and efficient delivery of hICOSL-TF mRNA to a variety of mammalian cells in vitro and in vivo. The LNPs used are formulated with SM-102, DSPC, cholesterol and DMG-PEG2000 at an optimal molar concentration for a high rate of encapsulation and efficient mRNA delivery. The hICOSL-TF protein is about 36 kD, consisting of hICOSL and a C-terminal TF tag (15 amino acids)
Lipid compositionSM-102/DSPC/Cholesterol/DMG-PEG2000
Technical NotesWork with mRNA-LNP on ice. It is important to minimize the time that the product spends at room temperature; after handling product during experiments, return immediately to ice.Upon receiving product, briefly pulse spin before opening to ensure product is at bottom of container; it is important not to spin for too long as this may rupture mRNA-LNP’s. Do not vortex. mRNA-LNP products should only be handled with certified RNAase-free reagents and consumables; use of filtered pipette tips is highly recommended
Encoding mRNAICOSLG
In Vitro QC (Cell Types)HEK293S
Technology ApplicationsProtein research
My Review for Clipos™ ICOSL-TF tag mRNA Lipid Nanoparticles

Required fields are marked with *

Overall Rating *
×
Related Products
Product Name Catalog Lipid composition Liposome Size Price
Clipos™ ICOSL-TF tag mRNA Lipid Nanoparticles CDL23-070-L SM-102/DSPC/Cholesterol/DMG-PEG2000 $1595
Clipos™ ICOSL-TF tag mRNA Lipid Nanoparticles CDPM09 SM-102/DSPC/cholesterol/DMG-PEG2000 INQUIRY
Clipos™ ICOSL-TF tag mRNA Lipid Nanoparticles CDL23-077-L SM-102/DSPC/Cholesterol/DMG-PEG2000 $1595
Clipos™ ICOSL-TF tag mRNA Lipid Nanoparticles CDPM12 SM-102/DSPC/cholesterol/DMG-PEG2000 INQUIRY
Clipos™ ICOSL-TF tag mRNA Lipid Nanoparticles CDPM08 SM-102/DSPC/cholesterol/DMG-PEG2000 INQUIRY
Clipos™ ICOSL-TF tag mRNA Lipid Nanoparticles CDL23-011-L SM-102/DSPC/Cholesterol/DMG-PEG2000 $1595
Clipos™ ICOSL-TF tag mRNA Lipid Nanoparticles CDL23-044-L SM-102/DSPC/Cholesterol/DMG-PEG2000 $1595
Clipos™ ICOSL-TF tag mRNA Lipid Nanoparticles CDL23-079-L SM-102/DSPC/Cholesterol/DMG-PEG2000 $1595
Products
Fill out the form below
to receive a quote

GET A QUOTE

Services

Drug Targeting Strategy

Drug Delivery Nanoparticles Formulation

Bioparticles Analysis and Characterization

Bioactive Particles & Fillers Production

Functional Biomedical Coatings

Lipid Library Development for Drug Delivery

Aptamer Targeted Drug Delivery System

Other Types of Drug Delivery

Products

Liposome System

Chelating Agents

Bioactive Matrixes

Porous Organic Materials

Biopolymers & Synthetic Polymers

PROTAC

Transfection

Exosome Products

Cleavable Linkers

Pharmaceutical Excipients (drug/medical grade)

Tissue Engineering Scaffold

  • (USA)
  • (Europe)
Cookie Policy | Privacy Policy | Copyright © CD Bioparticles. All rights reserved.
×
Upload products to cart

1. Download the template.

2. Enter product information on the template (maximum number of products: 200).

3. Load the file using selector below.

Drag and drop your file here or

Choose file
*.xlsx (max 20 MB)

4. Click the "Add to cart" button.

×
Upload products to quote list

1. Download the template.

2. Enter product information on the template (maximum number of products: 200).

3. Load the file using selector below.

Drag and drop your file here or

Choose file
*.xlsx (max 20 MB)

4. Click the "Add to quote" button.