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Clipos™ IL-4-TF tag mRNA Lipid Nanoparticles

Catalog:CDL23-044-L

Unit Size
Price
$1595

Buy Now Datasheet

Specifications QA & Reviews
StorageStore at 4°C
DescriptionInterleukin 4 (IL-4), encoded by the IL4 gene, is a pleiotropic cytokine known primarily for its role in type 2 immunity. IL-4 is mainly produced by mast cells, Th2 cells, eosinophils and basophils. By binding to its receptor IL-4R, this cytokine exerts many biological effects, including stimulation of proliferation of activated B and T cells, and differentiation of B cells into plasma cells. IL4 is considered a canonical regulatory cytokine because alternative activation of myeloid cells was first observed after stimulation with Th2 lymphocyte-derived IL4. IL4 is structurally and functionally related to another immunomodulatory cytokine, IL13. IL-4 has been found to be increased in breast, prostate, lung, renal cell, and other types of cancer, and IL-4R is overexpressed in many types of cancer, suggesting that IL-4 has a significant impact on tumor progression. This product is designed as a tool for the delivery and expression of TF-tagged human IL-4 mRNA for research. The product leverages the lipid nanoparticle (LNP) technology platform for simple and efficient delivery of hIL4-TF mRNA to a variety of mammalian cells in vitro and in vivo. The LNPs used are formulated with SM-102, DSPC, cholesterol and DMG-PEG2000 at an optimal molar concentration for a high rate of encapsulation and efficient mRNA delivery. The hIL4-TF protein is about 19 kD, consisting of hIL4 and a C-terminal TF tag (15 amino acids)
Lipid compositionSM-102/DSPC/Cholesterol/DMG-PEG2000
Technical NotesWork with mRNA-LNP on ice. It is important to minimize the time that the product spends at room temperature; after handling product during experiments, return immediately to ice.Upon receiving product, briefly pulse spin before opening to ensure product is at bottom of container; it is important not to spin for too long as this may rupture mRNA-LNP’s. Do not vortex. mRNA-LNP products should only be handled with certified RNAase-free reagents and consumables; use of filtered pipette tips is highly recommended
Encoding mRNAIL4
In Vitro QC (Cell Types)HEK293S
Technology ApplicationsProtein research
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