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Clipos™ TNF-alpha-TF tag mRNA Lipid Nanoparticles

Catalog:CDL23-046-L

Unit Size

200 μL

Price: $1595

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Specifications QA & Reviews

Storage	Store at 4°C
Description	Tumor necrosis factor (TNF or TNFα) is a multifunctional pro-inflammatory cytokine encoded by the TNF gene, which belongs to the TNF superfamily and consists of a variety of transmembrane proteins with homologous TNF domains. This cytokine is mainly secreted by macrophages. It triggers signaling through two receptors: TNFR1 and TNFR2. TNFR1 signaling tends to be pro-inflammatory and apoptotic, whereas TNFR2 signaling is anti-inflammatory and promotes cell proliferation. TNFα has been linked to a variety of diseases, including autoimmune diseases, insulin resistance, psoriasis, rheumatoid arthritis, ankylosing spondylitis, tuberculosis, autosomal dominant polycystic kidney disease, and cancer. This product is designed as a tool for the delivery and expression of TF-tagged human TNFα mRNA for research. The product leverages the lipid nanoparticle (LNP) technology platform for simple and efficient delivery of hTNFα-TF mRNA to a variety of mammalian cells in vitro and in vivo. The LNPs used are formulated with SM-102, DSPC, cholesterol and DMG-PEG2000 at an optimal molar concentration for a high rate of encapsulation and efficient mRNA delivery. The hTNFα-TF protein is about 28 kD, consisting of hTNFα and a C-terminal TF tag (15 amino acids)
Lipid composition	SM-102/DSPC/Cholesterol/DMG-PEG2000
Technical Notes	Work with mRNA-LNP on ice. It is important to minimize the time that the product spends at room temperature; after handling product during experiments, return immediately to ice.Upon receiving product, briefly pulse spin before opening to ensure product is at bottom of container; it is important not to spin for too long as this may rupture mRNA-LNP’s. Do not vortex. mRNA-LNP products should only be handled with certified RNAase-free reagents and consumables; use of filtered pipette tips is highly recommended
Encoding mRNA	TNF
In Vitro QC (Cell Types)	HEK293S
Technology Applications	Protein research

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