×
Shopping Cart
×
Quote List
0Quotes
0Cart

Clipos™ PD-L1-TF tag mRNA Lipid Nanoparticles(v3)

Catalog:CDL23-049-L

Unit Size
Price
$1595

Buy Now Need technical support? Datasheet

Specifications QA & Reviews
StorageStore at 4°C
DescriptionPD-L1 (programmed cell death protein ligand 1), also known as CD274, is a type 1 transmembrane protein mainly expressed on the cell surface of tumor cells or antigen-presenting cells. PD-1, (also known as CD274), is a membrane protein of the human immunoglobulin superfamily, expressed on the surface of T cells, primary B cells, and myeloid-derived dendritic cells. PD-1 and PD-L1 were also found to be co-expressed on the surface of SCLC cancer cells. PD-1/PD-L1 act as inhibitory checkpoint molecules in the immune system. PD-1 binds to PD-L1 to form a complex and transmit inhibitory signals to reduce the proliferation and activity of killer T lymphocytes. Blocking PD-1 with anti-PD-1 antibody, or blocking PD-L1 with anti-PD-L1 antibody, can inhibit the formation of PD-1/PD-L1 complex, thereby activating the immune system to attack tumors. Therefore, both anti-PD-1 and anti-PD-L1 antibodies have been used as adjuvant therapy for certain types of cancer. This product is designed as a tool for the delivery and expression of PDL-1 TF secreted mRNA for research. The product leverages the lipid nanoparticle (LNP) technology platform for simple and efficient delivery of PDL-1 TF secreted mRNA to a variety of mammalian cells in vitro and in vivo. The LNPs used are formulated with SM-102, DSPC, cholesterol and DMG-PEG2000 at an optimal molar concentration for a high rate of encapsulation and efficient mRNA delivery. This PDL-1 TF secreted fusion protein is approximately 26 kD, consisting of the PD-1 extracellular domain (ECD) and a C-terminal TF tag (15 amino acids)
Lipid compositionSM-102/DSPC/Cholesterol/DMG-PEG2000
Technical NotesWork with mRNA-LNP on ice. It is important to minimize the time that the product spends at room temperature; after handling product during experiments, return immediately to ice.Upon receiving product, briefly pulse spin before opening to ensure product is at bottom of container; it is important not to spin for too long as this may rupture mRNA-LNP’s. Do not vortex. mRNA-LNP products should only be handled with certified RNAase-free reagents and consumables; use of filtered pipette tips is highly recommended
Encoding mRNACD274
In Vitro QC (Cell Types)HEK293S
Technology ApplicationsProtein research
My Review for Clipos™ PD-L1-TF tag mRNA Lipid Nanoparticles(v3)

Required fields are marked with *

Overall Rating *
×
Related Products
Product Name Catalog Lipid composition Liposome Size Price
Clipos™ PD-L1-TF tag mRNA Lipid Nanoparticles(v3) CDPM08 SM-102/DSPC/cholesterol/DMG-PEG2000 INQUIRY
Clipos™ PD-L1-TF tag mRNA Lipid Nanoparticles(v3) CDSNT62 $1380
Clipos™ PD-L1-TF tag mRNA Lipid Nanoparticles(v3) CDL23-016-L SM-102/DSPC/Cholesterol/DMG-PEG2000 $1695
Clipos™ PD-L1-TF tag mRNA Lipid Nanoparticles(v3) CDL23-041-L SM-102/DSPC/Cholesterol/DMG-PEG2000 $1595
Clipos™ PD-L1-TF tag mRNA Lipid Nanoparticles(v3) CDL23-073-L SM-102/DSPC/Cholesterol/DMG-PEG2000 $1595
Clipos™ PD-L1-TF tag mRNA Lipid Nanoparticles(v3) CDL23-061-L SM-102/DSPC/Cholesterol/DMG-PEG2000 $1595
Clipos™ PD-L1-TF tag mRNA Lipid Nanoparticles(v3) CDPM10 SM-102/DSPC/cholesterol/DMG-PEG2000 INQUIRY
Clipos™ PD-L1-TF tag mRNA Lipid Nanoparticles(v3) CDL23-091-L SM-102/DSPC/Cholesterol/DMG-PEG2000 $1695
Products
Fill out the form below
to receive a quote

GET A QUOTE

Services

Drug Targeting Strategy

Drug Delivery Nanoparticles Formulation

Bioparticles Analysis and Characterization

Bioactive Particles & Fillers Production

Functional Biomedical Coatings

Lipid Library Development for Drug Delivery

Aptamer Targeted Drug Delivery System

Other Types of Drug Delivery

Products

Liposome System

Chelating Agents

Bioactive Matrixes

Porous Organic Materials

Biopolymers & Synthetic Polymers

PROTAC

Transfection

Exosome Products

Cleavable Linkers

Pharmaceutical Excipients (drug/medical grade)

Tissue Engineering Scaffold

  • (USA)
  • (Europe)
Cookie Policy | Privacy Policy | Copyright © CD Bioparticles. All rights reserved.
×
Upload products to cart

1. Download the template.

2. Enter product information on the template (maximum number of products: 200).

3. Load the file using selector below.

Drag and drop your file here or

Choose file
*.xlsx (max 20 MB)

4. Click the "Add to cart" button.

×
Upload products to quote list

1. Download the template.

2. Enter product information on the template (maximum number of products: 200).

3. Load the file using selector below.

Drag and drop your file here or

Choose file
*.xlsx (max 20 MB)

4. Click the "Add to quote" button.