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Clipos™ Anti-Mesothelin/CD3 bispecific mRNA Lipid Nanoparticles

Catalog:CDL23-051-L

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$1980

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StorageStore at 4°C
DescriptionMesothelin (or MSLN), encoded by the MSLN gene, is a glycosylphosphatidylinositol-linked membrane glycoprotein. This glycoprotein is expressed on the cell surface of mesothelioma and is overexpressed in a variety of human tumors, including mesothelioma, ovarian, pancreatic, lung adenocarcinoma, and cholangiocarcinoma. Mesothelin binds to MUC16, and this interaction may promote tumor engraftment and peritoneal spread through cell adhesion. A 64 amino acid region (residues 296-359) at the N-terminal of cell surface mesothelin has been identified as the functional binding domain (termed IAB) of MUC16. Mesothelin acts as a functional partner of MUC16 in cancer development. Therefore, mesothelin can be used as a tumor marker or as an antigenic target for therapeutic cancer vaccines. A human anti-mesothelin CAR has been constructed consisting of a human mesothelin-specific single-chain antibody variable fragment (P4 scFv) conjugated to a T-cell signaling domain. In human T cells cultured with mesothelin-expressing tumors, P4 CAR expression resulted in proinflammatory cytokine production, degranulation, and efficient cytolytic function and killing of mesothelin-negative cancer cells. This product is designed as a tool for the delivery and expression of anti-Meso P4 scFv/CD3 mutant Fc mRNA for research. The product leverages the lipid nanoparticle (LNP) technology platform for simple and efficient delivery of anti-Meso P4 scFv/CD3 mutant Fc mRNA to a variety of mammalian cells in vitro and in vivo. The LNPs used are formulated with SM-102, DSPC, cholesterol and DMG-PEG2000 at an optimal molar concentration for a high rate of encapsulation and efficient mRNA delivery. The anti-Meso P4 scFv/CD3 mutant Fc in this product is approximately 70 kD and consists of anti-Meso P4 scFv (single-chain variable fragment), mutant human Fc and CD3ze signaling domains
Lipid compositionSM-102/DSPC/Cholesterol/DMG-PEG2000
Technical NotesWork with mRNA-LNP on ice. It is important to minimize the time that the product spends at room temperature; after handling product during experiments, return immediately to ice.Upon receiving product, briefly pulse spin before opening to ensure product is at bottom of container; it is important not to spin for too long as this may rupture mRNA-LNP’s. Do not vortex. mRNA-LNP products should only be handled with certified RNAase-free reagents and consumables; use of filtered pipette tips is highly recommended
Encoding mRNAMSLN
In Vitro QC (Cell Types)HEK293S
Technology ApplicationsAntibody research
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