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Clipos™ mbIL-2-TF tag (tethered) mRNA Lipid Nanoparticles

Catalog:CDL23-061-L

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Price
$1595

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StorageStore at 4°C
DescriptionInterleukin 2 (IL-2) is an interleukin, a cytokine signaling molecule in the immune system, encoded by the IL2 gene. It is a secreted cytokine that belongs to the IL2 cytokine subfamily that includes IL4, IL7, IL9, IL15, IL21, erythropoietin, and thrombopoietin. IL-2 is a glycoprotein produced by activated CD4+ and CD8+ T lymphocytes and plays an important role in the proliferation of T lymphocytes and B lymphocytes. IL-2 signaling promotes the activation of various lymphocyte subtypes during cell differentiation through binding to its receptor IL-2R, resulting in an immune or homeostatic response. Due to its role in influencing the differentiation of T helper cells that influence the course of the immune response, IL-2 has been implicated in autoimmune diseases, leading to the development of many therapeutic agents for different autoimmune diseases. This product is designed as a tool for the delivery and expression of membrane-bound IL-2-TF mRNA for research. The product leverages the lipid nanoparticle (LNP) technology platform for simple and efficient delivery of membrane-bound IL-2-TF mRNA to a variety of mammalian cells in vitro and in vivo. The LNPs used are formulated with SM-102, DSPC, cholesterol and DMG-PEG2000 at an optimal molar concentration for a high rate of encapsulation and efficient mRNA delivery. The membrane-bound IL-2-TF fusion protein is approximately 49 kD, consisting of human IL-2 (153 amino acids) and human IL-2Rα (272 amino acids) with a C-terminal TF tag (15 amino acids) in between
Lipid compositionSM-102/DSPC/Cholesterol/DMG-PEG2000
Technical NotesWork with mRNA-LNP on ice. It is important to minimize the time that the product spends at room temperature; after handling product during experiments, return immediately to ice.Upon receiving product, briefly pulse spin before opening to ensure product is at bottom of container; it is important not to spin for too long as this may rupture mRNA-LNP’s. Do not vortex. mRNA-LNP products should only be handled with certified RNAase-free reagents and consumables; use of filtered pipette tips is highly recommended
Encoding mRNAIL2
In Vitro QC (Cell Types)HEK293S
Technology ApplicationsProtein research
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