×
Shopping Cart
×
Quote List
0Quotes
0Cart

Clipos™ Human Anti-CS1 CAR-TF tag mRNA Lipid Nanoparticles

Catalog:CDL23-064-L

Unit Size
Price
$1980

Buy Now Datasheet

Specifications QA & Reviews
StorageStore at 4°C
DescriptionCS1 (CD2 subset-1), also known as CD319 (SLAMF7), is a human natural killer (NK) cell receptor encoded by the SLAMF7 gene. This surface antigen is a robust marker of normal and malignant plasma cells in multiple myeloma. Human NK cells express two splice variants of CS1: CS1-S lacks an intracellular domain for activation, while CS1-L contains an intracellular domain and is therefore capable of activating NK cytotoxicity. CS1 is a homophilic receptor, and CS1-CS1 interaction leads to the activation of natural cytotoxicity of NK cells. Both isoforms of CS1 are membrane bound and expressed in NK cells. However, only the CS1-L isoform is expressed in B cells and regulates B cell proliferation and autocrine. This product is designed as a tool for the delivery and expression of human anti-CS1-TF CAR mRNA for research. The product leverages the lipid nanoparticle (LNP) technology platform for simple and efficient delivery of human anti-CS1-TF CAR mRNA to a variety of mammalian cells in vitro and in vivo. The LNPs used are formulated with SM-102, DSPC, cholesterol and DMG-PEG2000 at an optimal molar concentration for a high rate of encapsulation and efficient mRNA delivery. The human anti-CS1-TF CAR in this product is approximately 58 kD, consisting of human anti-CS1 scFv (single-chain variable fragment) linked to a second-generation CAR (chimeric antigen receptor) containing the CD8 hinge and transmembrane domain and 4-1BB and CD3ζ signaling domains. It contains an additional C-terminal TF tag (15 amino acids)
Lipid compositionSM-102/DSPC/Cholesterol/DMG-PEG2000
Technical NotesWork with mRNA-LNP on ice. It is important to minimize the time that the product spends at room temperature; after handling product during experiments, return immediately to ice.Upon receiving product, briefly pulse spin before opening to ensure product is at bottom of container; it is important not to spin for too long as this may rupture mRNA-LNP’s. Do not vortex. mRNA-LNP products should only be handled with certified RNAase-free reagents and consumables; use of filtered pipette tips is highly recommended
Encoding mRNACD319
In Vitro QC (Cell Types)HEK293S
Technology ApplicationsCAR-T
My Review for Clipos™ Human Anti-CS1 CAR-TF tag mRNA Lipid Nanoparticles

Required fields are marked with *

Overall Rating *
×
Related Products
Product Name Catalog Lipid composition Liposome Size Price
Clipos™ Human Anti-CS1 CAR-TF tag mRNA Lipid Nanoparticles CDL23-073-L SM-102/DSPC/Cholesterol/DMG-PEG2000 $1595
Clipos™ Human Anti-CS1 CAR-TF tag mRNA Lipid Nanoparticles CDL23-060-L SM-102/DSPC/Cholesterol/DMG-PEG2000 $1595
Clipos™ Human Anti-CS1 CAR-TF tag mRNA Lipid Nanoparticles CDL23-074-L SM-102/DSPC/Cholesterol/DMG-PEG2000 $1595
Clipos™ Human Anti-CS1 CAR-TF tag mRNA Lipid Nanoparticles CDL23-059-L SM-102/DSPC/Cholesterol/DMG-PEG2000 $1595
Clipos™ Human Anti-CS1 CAR-TF tag mRNA Lipid Nanoparticles CDL23-046-L SM-102/DSPC/Cholesterol/DMG-PEG2000 $1595
Clipos™ Human Anti-CS1 CAR-TF tag mRNA Lipid Nanoparticles CDPM14 SM-102/DSPC/cholesterol/DMG-PEG2000 INQUIRY
Clipos™ Human Anti-CS1 CAR-TF tag mRNA Lipid Nanoparticles CDL23-031-L SM-102/DSPC/Cholesterol/DMG-PEG2000 $1980
Clipos™ Human Anti-CS1 CAR-TF tag mRNA Lipid Nanoparticles CDL23-016-L SM-102/DSPC/Cholesterol/DMG-PEG2000 $1695
Products
Fill out the form below
to receive a quote

GET A QUOTE

Services

Drug Targeting Strategy

Drug Delivery Nanoparticles Formulation

Bioparticles Analysis and Characterization

Bioactive Particles & Fillers Production

Functional Biomedical Coatings

Lipid Library Development for Drug Delivery

Aptamer Targeted Drug Delivery System

Other Types of Drug Delivery

Products

Liposome System

Chelating Agents

Bioactive Matrixes

Porous Organic Materials

Biopolymers & Synthetic Polymers

PROTAC

Transfection

Exosome Products

Cleavable Linkers

Pharmaceutical Excipients (drug/medical grade)

Tissue Engineering Scaffold

  • (USA)
  • (Europe)
Cookie Policy | Privacy Policy | Copyright © CD Bioparticles. All rights reserved.
×
Upload products to cart

1. Download the template.

2. Enter product information on the template (maximum number of products: 200).

3. Load the file using selector below.

Drag and drop your file here or

Choose file
*.xlsx (max 20 MB)

4. Click the "Add to cart" button.

×
Upload products to quote list

1. Download the template.

2. Enter product information on the template (maximum number of products: 200).

3. Load the file using selector below.

Drag and drop your file here or

Choose file
*.xlsx (max 20 MB)

4. Click the "Add to quote" button.