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Clipos™ SIGLEC-7-TF tag mRNA Lipid Nanoparticles

Catalog:CDL23-076-L

Unit Size
Price
$1595

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Specifications QA & Reviews
StorageStore at 4°C
DescriptionSIGLEC7, also known as CD328, is a protein belonging to the sialic acid-binding immunoglobulin-like lectin (SIGLEC) family, encoded by the SIGLEC7 gene. Proteins of this family are expressed on the surface of immune cells, are a subset of type I lectins, and bind sialic acid. These SIGLEC proteins have been designated as glycoimmune checkpoints. Their ligands are sialylated glycan proteins that are abnormally expressed on tumor cells. Inhibitory SIGLECs (e.g. SIGLEC-7 and -9) are found on immune cells such as natural killer (NK) and T cells by interacting with their ligands and inhibit immune signaling pathways to dampen immune responses. Studies have found that SIGLEC-7 is associated with a reduction in CD8+ T cell effector functions, including cytotoxicity and cytokine production. SIGLEC-7 was found to be highly expressed in primary leukemia cells and stem cells from patients with acute myeloid leukemia (AML). This may adversely affect the effector responses of SIGLEC-7+ CD8+ T cells in the blood and bone marrow of AML patients. This product is designed as a tool for the delivery and expression of human TF tagged SIGLEC7 mRNA for research. The product leverages the lipid nanoparticle (LNP) technology platform for simple and efficient delivery of SIGLEC7-TF mRNA to a variety of mammalian cells in vitro and in vivo. The LNPs used are formulated with SM-102, DSPC, cholesterol and DMG-PEG2000 at an optimal molar concentration for a high rate of encapsulation and efficient mRNA delivery. The SIGLEC7-TF fusion protein is approximately 53 kD, consisting of SIGLEC7 (467 amino acids) and a C-terminal TF tag (15 amino acids)
Lipid compositionSM-102/DSPC/Cholesterol/DMG-PEG2000
Technical NotesWork with mRNA-LNP on ice. It is important to minimize the time that the product spends at room temperature; after handling product during experiments, return immediately to ice.Upon receiving product, briefly pulse spin before opening to ensure product is at bottom of container; it is important not to spin for too long as this may rupture mRNA-LNP’s. Do not vortex. mRNA-LNP products should only be handled with certified RNAase-free reagents and consumables; use of filtered pipette tips is highly recommended
Encoding mRNASIGLEC7
In Vitro QC (Cell Types)HEK293S
Technology ApplicationsProtein research
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