×
Shopping Cart
×
Quote List
0Quotes
0Cart

Clipos™ IL-15-IL15Ralpha mRNA Lipid Nanoparticles

Catalog:CDL23-079-L

Unit Size
Price
$1595

Buy Now Datasheet

Specifications QA & Reviews
StorageStore at 4°C
DescriptionInterleukin 15 (IL-15), encoded by the IL-15 gene, is a member of the family of four alpha-helical bundles of cytokines. The primary mechanism of action of IL-15 appears to be juxtacrine signaling determined by cell-cell contacts. This role also includes endocrine and reverse signaling. IL-15 was initially characterized as a soluble molecule, but it was later found that the major form of IL-15 protein is the membrane-bound form, which can be directly bound to the cell membrane or presented by the IL-15Rα receptor. The IL-15 receptor consists of three subunits: IL-15Rα, CD122, and CD132. CD122 and CD132 are shared with the IL-2 receptor, and there is actually an additional subunit (CD25). The shared subunits contain cytoplasmic motifs required for signal transduction that underlie many of the overlapping biological activities of IL-15 and IL-2. IL-15Rα is a subunit that specifically binds IL-15 with very high affinity and can bind IL-15 independently of other subunits. This property suggests that IL-15 is able to transmit signals between multiple cells. This product is designed as a tool for the delivery and expression of IL-15-IL15Rα mRNA for research. The product leverages the lipid nanoparticle (LNP) technology platform for simple and efficient delivery of IL-15-IL15Rα mRNA to a variety of mammalian cells in vitro and in vivo. The LNPs used are formulated with SM-102, DSPC, cholesterol and DMG-PEG2000 at an optimal molar concentration for a high rate of encapsulation and efficient mRNA delivery. The IL-15-IL15Rα fusion protein is approximately 59 kD, consisting of full-length human IL-15 (162 amino acids) and IL15Rα (353 amino acids) with 15-residue peptide linker GGGGSGGGGSGGGGS between them
Lipid compositionSM-102/DSPC/Cholesterol/DMG-PEG2000
Technical NotesWork with mRNA-LNP on ice. It is important to minimize the time that the product spends at room temperature; after handling product during experiments, return immediately to ice.Upon receiving product, briefly pulse spin before opening to ensure product is at bottom of container; it is important not to spin for too long as this may rupture mRNA-LNP’s. Do not vortex. mRNA-LNP products should only be handled with certified RNAase-free reagents and consumables; use of filtered pipette tips is highly recommended
Encoding mRNAIL-15
In Vitro QC (Cell Types)HEK293S
Technology ApplicationsProtein research
My Review for Clipos™ IL-15-IL15Ralpha mRNA Lipid Nanoparticles

Required fields are marked with *

Overall Rating *
×
Related Products
Product Name Catalog Lipid composition Liposome Size Price
Clipos™ IL-15-IL15Ralpha mRNA Lipid Nanoparticles CDL23-045-L SM-102/DSPC/Cholesterol/DMG-PEG2000 $1595
Clipos™ IL-15-IL15Ralpha mRNA Lipid Nanoparticles CDL23-036-L SM-102/DSPC/Cholesterol/DMG-PEG2000 $1595
Clipos™ IL-15-IL15Ralpha mRNA Lipid Nanoparticles CDL23-070-L SM-102/DSPC/Cholesterol/DMG-PEG2000 $1595
Clipos™ IL-15-IL15Ralpha mRNA Lipid Nanoparticles CDL23-022-L SM-102/DSPC/Cholesterol/DMG-PEG2000 $1595
Clipos™ IL-15-IL15Ralpha mRNA Lipid Nanoparticles CDL23-082-L SM-102/DSPC/Cholesterol/DMG-PEG2000 $1695
Clipos™ IL-15-IL15Ralpha mRNA Lipid Nanoparticles CDSNT63 $1380
Clipos™ IL-15-IL15Ralpha mRNA Lipid Nanoparticles CDPM08 SM-102/DSPC/cholesterol/DMG-PEG2000 INQUIRY
Clipos™ IL-15-IL15Ralpha mRNA Lipid Nanoparticles CDL23-050-L SM-102/DSPC/Cholesterol/DMG-PEG2000 $1595
Products
Fill out the form below
to receive a quote

GET A QUOTE

Services

Drug Targeting Strategy

Drug Delivery Nanoparticles Formulation

Bioparticles Analysis and Characterization

Bioactive Particles & Fillers Production

Functional Biomedical Coatings

Lipid Library Development for Drug Delivery

Aptamer Targeted Drug Delivery System

Other Types of Drug Delivery

Products

Liposome System

Chelating Agents

Bioactive Matrixes

Porous Organic Materials

Biopolymers & Synthetic Polymers

PROTAC

Transfection

Exosome Products

Cleavable Linkers

Pharmaceutical Excipients (drug/medical grade)

Tissue Engineering Scaffold

  • (USA)
  • (Europe)
Cookie Policy | Privacy Policy | Copyright © CD Bioparticles. All rights reserved.
×
Upload products to cart

1. Download the template.

2. Enter product information on the template (maximum number of products: 200).

3. Load the file using selector below.

Drag and drop your file here or

Choose file
*.xlsx (max 20 MB)

4. Click the "Add to cart" button.

×
Upload products to quote list

1. Download the template.

2. Enter product information on the template (maximum number of products: 200).

3. Load the file using selector below.

Drag and drop your file here or

Choose file
*.xlsx (max 20 MB)

4. Click the "Add to quote" button.