×
Shopping Cart
×
Quote List

Clipos™ IL-15-eGFP mRNA Lipid Nanoparticles


Catalog:CDL23-080-L

Unit Size
Price
$1595

Buy Now Need technical support? Datasheet

StorageStore at 4°C
DescriptionInterleukin 15 (IL-15), encoded by the IL-15 gene, is a member of the family of four alpha-helical bundles of cytokines. The primary mechanism of action of IL-15 appears to be juxtacrine signaling determined by cell-cell contacts. This role also includes endocrine and reverse signaling. IL-15 was initially characterized as a soluble molecule, but it was later found that the major form of IL-15 protein is the membrane-bound form, which can be directly bound to the cell membrane or presented by the IL-15Rα receptor. The IL-15 receptor consists of three subunits: IL-15Rα, CD122, and CD132. CD122 and CD132 are shared with the IL-2 receptor, and there is actually an additional subunit (CD25). The shared subunits contain cytoplasmic motifs required for signal transduction that underlie many of the overlapping biological activities of IL-15 and IL-2. IL-15Rα is a subunit that specifically binds IL-15 with very high affinity and can bind IL-15 independently of other subunits. This property suggests that IL-15 is able to transmit signals between multiple cells. This product is designed as a tool for the delivery and expression of eGFP-tagged IL-15 mRNA for research. The product leverages the lipid nanoparticle (LNP) technology platform for simple and efficient delivery of IL-15-eGFP mRNA to a variety of mammalian cells in vitro and in vivo. The LNPs used are formulated with SM-102, DSPC, cholesterol and DMG-PEG2000 at an optimal molar concentration for a high rate of encapsulation and efficient mRNA delivery. The IL-15-eGFP fusion protein is approximately 59 kD, consisting of full-length human IL-15 (162 amino acids) and eGFP (262 amino acids) with 15-residue peptide linker GGGGSGGGGSGGGGS between them
Lipid compositionSM-102/DSPC/Cholesterol/DMG-PEG2000
Technical NotesWork with mRNA-LNP on ice. It is important to minimize the time that the product spends at room temperature; after handling product during experiments, return immediately to ice.Upon receiving product, briefly pulse spin before opening to ensure product is at bottom of container; it is important not to spin for too long as this may rupture mRNA-LNP’s. Do not vortex. mRNA-LNP products should only be handled with certified RNAase-free reagents and consumables; use of filtered pipette tips is highly recommended
Encoding mRNAIL-15
In Vitro QC (Cell Types)HEK293S
Technology ApplicationsProtein research
My Review for Clipos™ IL-15-eGFP mRNA Lipid Nanoparticles

Required fields are marked with *

Overall Rating *
×
Related Products
Product Name Catalog Lipid composition Liposome Size Price
Clipos™ IL-15-eGFP mRNA Lipid Nanoparticles CDL23-033-L SM-102/DSPC/Cholesterol/DMG-PEG2000 $1980
Clipos™ IL-15-eGFP mRNA Lipid Nanoparticles CDL23-072-L SM-102/DSPC/Cholesterol/DMG-PEG2000 $1595
Clipos™ IL-15-eGFP mRNA Lipid Nanoparticles CDL23-074-L SM-102/DSPC/Cholesterol/DMG-PEG2000 $1595
Clipos™ IL-15-eGFP mRNA Lipid Nanoparticles CDPM05 INQUIRY
Clipos™ IL-15-eGFP mRNA Lipid Nanoparticles CDL23-094-L SM-102/DSPC/Cholesterol/DMG-PEG2000 $1595
Clipos™ IL-15-eGFP mRNA Lipid Nanoparticles CDL23-013-L SM-102/DSPC/Cholesterol/DMG-PEG2000 $1595
Clipos™ IL-15-eGFP mRNA Lipid Nanoparticles CDL23-060-L SM-102/DSPC/Cholesterol/DMG-PEG2000 $1595
Clipos™ IL-15-eGFP mRNA Lipid Nanoparticles CDL23-095-L SM-102/DSPC/Cholesterol/DMG-PEG2000 $1328
Products
Fill out the form below
to receive a quote

GET A QUOTE

Cookie Policy | Privacy Policy | Copyright © CD Bioparticles. All rights reserved.
×
Upload products to cart

1. Download the template.

2. Enter product information on the template (maximum number of products: 200).

3. Load the file using selector below.

Drag and drop your file here or

Choose file
*.xlsx (max 20 MB)

4. Click the "Add to cart" button.

×
Upload products to quote list

1. Download the template.

2. Enter product information on the template (maximum number of products: 200).

3. Load the file using selector below.

Drag and drop your file here or

Choose file
*.xlsx (max 20 MB)

4. Click the "Add to quote" button.