Storage | Store at 4°C |
Description | CD19 is a well-known biomarker expressed on most normal and malignant B cells and used as a target antigen found in B cell malignancies. CD19, also known as B lymphocyte antigen CD19, B lymphocyte surface antigen B4, T cell surface antigen Leu-12, and CVID3, is a transmembrane protein encoded by the gene CD19 in humans. This 95 kd transmembrane glycoprotein belongs to the immunoglobulin superfamily with two extracellular C2 group Ig-like domains and a relatively large cytoplasmic tail that is highly conserved across mammalian species. CD19 is expressed on all normal, mitogen-stimulated, and malignant B cells, with the exception of plasma cells. CD19 is ubiquitously expressed at all stages of B cell development and its surface expression is highly regulated. Because it is ubiquitously present on all B cells, it can serve as a B cell marker and a target for immunotherapy against neoplastic lymphocytes. This product is designed as a tool for the delivery and expression of anti-CD19 scFv/CD3 mutant Fc mRNA for research. The product leverages the lipid nanoparticle (LNP) technology platform for simple and efficient delivery of anti-CD19 scFv/CD3 mutant Fc mRNA to a variety of mammalian cells in vitro and in vivo. The LNPs used are formulated with SM-102, DSPC, cholesterol and DMG-PEG2000 at an optimal molar concentration for a high rate of encapsulation and efficient mRNA delivery. The anti-CD19 scFv/CD3 mutant Fc in this product is approximately 70 kD and consists of anti-CD19 scFv (single-chain variable fragment), mutant human Fc and CD3ze signaling domains |
Lipid composition | SM-102/DSPC/Cholesterol/DMG-PEG2000 |
Technical Notes | Work with mRNA-LNP on ice. It is important to minimize the time that the product spends at room temperature; after handling product during experiments, return immediately to ice.Upon receiving product, briefly pulse spin before opening to ensure product is at bottom of container; it is important not to spin for too long as this may rupture mRNA-LNP’s. Do not vortex. mRNA-LNP products should only be handled with certified RNAase-free reagents and consumables; use of filtered pipette tips is highly recommended |
Encoding mRNA | CD19 |
In Vitro QC (Cell Types) | HEK293S |
Technology Applications | Protein research |
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×Product Name | Catalog | Lipid composition | Liposome Size | Price |
---|---|---|---|---|
Clipos™ Anti-CD19/CD3 bispecific mRNA Lipid Nanoparticles | CDSNT80 | $1380 | ||
Clipos™ Anti-CD19/CD3 bispecific mRNA Lipid Nanoparticles | CDL23-056-L | SM-102/DSPC/Cholesterol/DMG-PEG2000 | $1595 | |
Clipos™ Anti-CD19/CD3 bispecific mRNA Lipid Nanoparticles | CDL23-051-L | SM-102/DSPC/Cholesterol/DMG-PEG2000 | $1980 | |
Clipos™ Anti-CD19/CD3 bispecific mRNA Lipid Nanoparticles | CDL23-053-L | SM-102/DSPC/Cholesterol/DMG-PEG2000 | $1695 | |
Clipos™ Anti-CD19/CD3 bispecific mRNA Lipid Nanoparticles | CDL23-048-L | SM-102/DSPC/Cholesterol/DMG-PEG2000 | $1595 | |
Clipos™ Anti-CD19/CD3 bispecific mRNA Lipid Nanoparticles | CDL23-067-L | SM-102/DSPC/Cholesterol/DMG-PEG2000 | $1980 | |
Clipos™ Anti-CD19/CD3 bispecific mRNA Lipid Nanoparticles | CDL23-059-L | SM-102/DSPC/Cholesterol/DMG-PEG2000 | $1595 | |
Clipos™ Anti-CD19/CD3 bispecific mRNA Lipid Nanoparticles | CDL23-049-L | SM-102/DSPC/Cholesterol/DMG-PEG2000 | $1595 |
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3. Load the file using selector below.