Sito-Lipid Nanoparticles

Catalog:CDCLP24-007-L

Unit Size:

5 mL

Specifications QA & Reviews

Description

The formulation was taken from the literature DOI: 10.1021/acsnano.2c05647. The LNPs were able to enhance the efficiency of mRNA transmission, with an increase in the concentration of PEG in the LNPs augmenting shear resistance and mucus permeability, whereas β-sitosterol provided the LNPs with a polyhedral shape that facilitated endosomal escape. This formulation is suitable for inhaled mRNA lung disease treatment.

Lipid composition

DLin-MC3-DMA/β-sitosterol/DMG-PEG2K/DSPC (50:36.5:3.5:10, mole ratio)

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