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113-O12B-Lipid Nanoparticles (Targeted to Lymph Nodes)

Catalog:CDCLP24-013-L

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DescriptionThe formulation is from the literature DOI: 10.1073/pnas.2207841119. The special lipids synthesised enable specific targeting of lymph nodes, and the formulation can be used to develop mRNA cancer-targeted vaccines without the need to modify any of the active targeting ligands. Compared with LNPs formulated with ALC-0315, a key component in the US Food and Drug Administration (FDA)-approved Comirnaty, 113-O12B showed significantly reduced mRNA expression in the liver and higher expression in LNs after subcutaneous (SC) injection.
Lipid composition113-O12B/Chol/DOPE/DMG-PEG (16:4.8:3:2.4, mole ratio)

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