March 13, 2025 - Baltimore, MD 21205, USA
| Structure |
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| Storage | Please store the product under the recommended conditions in the Certificate of Analysis |
| Description | Gint4.T aptamer sodium is a nuclease-resistant RNA aptamer-based antagonist targeting platelet-derived growth factor receptor beta (PDGFRβ) (Kd: 9.6 nM). Gint4.T aptamer sodium inhibits PDGFRβ heterodimerization and EGFR transactivation. It can significantly inhibit cell migration and proliferation, induce differentiation and prevent tumor growth in vivo. Gint4.T aptamer sodium specifically inhibits PDGFRβ-mediated tropism of mesenchymal stem cells (MSCs) toward the tumor microenvironment. |
| Technology Applications | Cancer |
Catalog: CDAPT24-064-L
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Catalog: CDAPT24-065-L
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Datasheet