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Gint4.T aptamer sodium


Gint4.T aptamer sodium

Catalog:CDAPT24-008-L

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INQUIRY Datasheet

Structure Gint4.T aptamer sodium
StoragePlease store the product under the recommended conditions in the Certificate of Analysis
DescriptionGint4.T aptamer sodium is a nuclease-resistant RNA aptamer-based antagonist targeting platelet-derived growth factor receptor beta (PDGFRβ) (Kd: 9.6 nM). Gint4.T aptamer sodium inhibits PDGFRβ heterodimerization and EGFR transactivation. It can significantly inhibit cell migration and proliferation, induce differentiation and prevent tumor growth in vivo. Gint4.T aptamer sodium specifically inhibits PDGFRβ-mediated tropism of mesenchymal stem cells (MSCs) toward the tumor microenvironment.
Technology ApplicationsCancer
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