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ARC19499


ARC19499

Catalog:CDAPT24-045-L

Unit Size:

INQUIRY Datasheet

SynonymBAX499
Structure ARC19499
Storage-20°C, sealed storage, away from moisture
CAS No.1350667-54-7
DescriptionARC19499 is an aptamer that inhibits tissue factor pathway inhibitor (TFPI) , thereby enabling clot initiation and propagation via the extrinsic pathway. The core aptamer binds tightly and specifically to TFPI. ARC19499 blocks TFPI inhibition of both factor Xa and the TF/factor VIIa complex. ARC19499 corrects thrombin generation in hemophilia A and B plasma and restores clotting in FVIII-neutralized whole blood.
Formula Weight11078.95
Technology ApplicationsOthers
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