Short Name | ARC19499 |
Description | ARC19499 is an aptamer that inhibits tissue factor pathway inhibitor (TFPI) , thereby enabling clot initiation and propagation via the extrinsic pathway. The core aptamer binds tightly and specifically to TFPI. ARC19499 blocks TFPI inhibition of both factor Xa and the TF/factor VIIa complex. ARC19499 corrects thrombin generation in hemophilia A and B plasma and restores clotting in FVIII-neutralized whole blood. |
Technology Applications | Others |
Structure |
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Storage | -20°C, sealed storage, away from moisture |
Synonym | BAX499 |
Formula Weight | 11078.95 |
CAS No. | 1350667-54-7 |
Affinity & Target | Factor Xa |
Catalog: CDAPT24-001-L
Catalog: CDAPT24-002-L
Catalog: CDAPT24-003-L
Catalog: CDAPT24-004-L
Catalog: CDAPT24-005-L
Catalog: CDAPT24-006-L
Catalog: CDAPT24-007-L
Catalog: CDAPT24-008-L