ARC19499 sodium


ARC19499 sodium

ARC19499 sodium

Catalog:CDAPT24-046-L

Unit Size:1 mg, 5 mg, 10 mg

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Short Name ARC19499 sodium
Description ARC19499 sodium is an aptamer that inhibits tissue factor pathway inhibitor (TFPI) , thereby enabling clot initiation and propagation via the extrinsic pathway. The core aptamer binds tightly and specifically to TFPI. ARC19499 sodium blocks TFPI inhibition of both factor Xa and the TF/factor VIIa complex. ARC19499 sodium corrects thrombin generation in hemophilia A and B plasma and restores clotting in FVIII-neutralized whole blood.
Technology Applications Others
Structure ARC19499 sodium
Appearance White to off-white
Storage -20°C, sealed storage, away from moisture
Synonym BAX499 sodium
Formula Weight 11837.60
Affinity & Target Factor Xa

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