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1,2-Dioleoyl-sn–glycero-3-phosphoethanolamine (DOPE)-polyethylene glycol-carboxylic acid


1,2-Dioleoyl-sn–glycero-3-phosphoethanolamine (DOPE)-polyethylene glycol-carboxylic acid

DOPE-PEG-COOH

Catalog:CDN2142

Unit Size
Price
$950

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Common Use1,2-Dioleoyl-sn–glycero-3-phosphoethanolamine (DOPE)-polyethylene glycol-carboxylic acid (DOPE-PEG-COOH) is a linear heterobifunctional PEGylation reagent with an unsaturated DOPE phospholipid and carboxylic acid. DOPE-PEG-COOH is used to modify liposome surface with biomolecules containing amine groups. It is a useful self-assembling reagent to prepare grafted or PEGylated liposome or micelle while also providing an amine group for bioconjugation. It is often used in targeted drug delivery with the lipid bilayer to improve drug solubility, the PEG to provide stealth property, extend circulation half-life and reduce non-specific protein binding or cell adhesion, and the amine group to bioconjugate targeting molecules including antibody, aptamer, protein, and peptide.
Structure 1,2-Dioleoyl-sn–glycero-3-phosphoethanolamine (DOPE)-polyethylene glycol-carboxylic acid
PEG Molecular Weight3,400 Da
Functional GroupDOPE/COOH
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