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1,2-Dioleoyl-sn–glycero-3-phosphoethanolamine (DOPE)-polyethylene glycol-Maleimide


1,2-Dioleoyl-sn–glycero-3-phosphoethanolamine (DOPE)-polyethylene glycol-Maleimide

DOPE-PEG-MAL

Catalog:CDN2144

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$950

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Common Use1,2-Dioleoyl-sn–glycero-3-phosphoethanolamine (DOPE)-polyethylene glycol-Maleimide (DOPE-PEG-Mal) is a linear heterobifunctional PEGylation reagent with an unsaturated DOPE phospholipid and maleimide group. DOPE-PEG-Mal is used to modify liposome surface with biomolecules containing thiol groups. It is a useful self-assembling reagent to prepare grafted or PEGylated liposome or micelle while also providing an amine group for bioconjugation. It is often used in targeted drug delivery with the lipid bilayer to improve drug solubility, the PEG to provide stealth property, extend circulation half-life and reduce non-specific protein binding or cell adhesion, and the amine group to bioconjugate targeting molecules including antibody, aptamer, protein, and peptide.
Structure 1,2-Dioleoyl-sn–glycero-3-phosphoethanolamine (DOPE)-polyethylene glycol-Maleimide
PEG Molecular Weight1,000 Da
Functional GroupDOPE/Maleimide
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