Common Use | 1,2-Distearoyl-sn-Glycero-3-Phosphoethanolamine (DSPE)-polyethylene glycol-amine (DSPE-PEG-Amine, DSPE-PEG-NH2) is a linear heterobifunctional PEGylation reagent with a DSPE phospholipid and an amine. DSPE-PEG-NH2 is used to modify liposome surface with biomolecules containing amine reactive groups (NHS, thiolate). It is a useful self-assembling reagent to prepare grafted or PEGylated liposome or micelle while also providing an amine group for bioconjugation. It is often used in targeted drug delivery with the lipid bilayer to improve drug solubility, the PEG to provide stealth property, extend circulation half-life and reduce non-specific protein binding or cell adhesion, and the amine group to bioconjugate targeting molecules including antibody, aptamer, protein, and peptide. |
Structure | |
PEG Molecular Weight | 600 Da |
Functional Group | DSPE/Amine |
Catalog: CDA-3016
Catalog: CDN2195
Catalog: CDP23-0516
Catalog: CDA-3005
Catalog: CDP23-0041
Catalog: CDN2156
Catalog: CDN2217
Catalog: CDP23-0032
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