Common Use | DSPE-PEG-Vinylsulfone (DSPE-PEG-VS) is a linear heterobifunctional PEGylation reagent with a DSPE phospholipid and a biotin. It is a useful self-assembling reagent to prepare grafted or PEGylated liposome or micelle which has functional vinylsulfone on the surface that can react with thiol-containing peptides or antibodies. It is often used in targeted drug delivery with the lipid bilayer to improve drug solubility, the PEG to provide stealth property, extend circulation half-life and reduce non-specific protein binding or cell adhesion, and the VS group to bind to targeting molecules including antibody, aptamer, protein, and peptide. |
Structure | |
PEG Molecular Weight | 3,400 Da |
Functional Group | DSPE/Vinylsulfone |
Catalog: CDN2176
Catalog: CDN2211
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Catalog: CDP23-0598
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