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Clipos™ Natural Phosphatidylserine (PS) Lipid Liposomes

Catalog:CDECPS-1605

Unit Size
Price
$2300

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Specifications QA & Reviews
StorageShould always be stored at in the dark at 4 °C, except when brought to room temperature for brief periods prior to animal dosing. DO NOT FREEZE. If the suspension is frozen, the encapsulated drug can be released from the liposomes thus limiting its effectiveness. In addition, that the size of the liposomes will also change upon freezing and thawing.
AppearanceWhite translucent liquid made of nano size unilamellar liposomes. Usually due to the small size of liposomes no settling will occur in the bottom of the vial. The liposomes are packaged in an amber vial.
DescriptionNatural Phosphatidylserine (PS)-based Liposomes are composed of four liposomes made from phosphatidylserine (PS) lipids that are made from natural lipids that are extracted from either brain or soybean. Adding 30% cholesterol makes the liposomes serum stable and is necessary when the liposomes are used in the presence of serum. These liposomes are all anionic due to the negative charge of phosphatidylserine. Brain phosphatidylserine (PS) is composed of both saturated and unsaturated lipids. Brain PS contains much larger percentage of saturated lipids compare to Soy PS. Brain PS is mainly composed of four lipids: 42% of 18:0 lipid, 30% of 18:1 lipid, 2% of 20:4 lipid and 11% of 22:6 lipid.
Lipid compositionBrain PS/Cholesterol (70/30 molar ratio)
Liposome Size100 nm
Lipid Molar Concentration10 mM
BufferPhosphate Buffered Saline, pH 7.4
Shelf-life4 months.
Technical NotesLiposomes are unilamellar and sized to 100 nm. If you need them to be made in another size then you should mention that at the time of ordering. Unilamellar liposomes can be made in 50 nm and 200 nm sizes. Liposomes that are larger than 200 nm are multilamellar structure. Liposomes are made in PBS buffer at pH 7.4 but it can be made in any other buffer of your choice. You can specify your buffer at the time of ordering. Liposomes are made in degassed buffer that is purged with argon to avoid oxidation of the unsaturated phospholipids. Liposomes are made under sterile condition. Liposomes are unilamellar and therefore due to their small size they will not settle in the bottom of the vial. If you need to take multiple aliquots out of the vial during a period of time, then it is advised to take extreme care in not contaminating the vial. It is recommended to handle the vial under a sterile hood to maintain the sterility of the product. Liposomes should never be frozen. Crystal ice that is formed during freezing will rupture the lipid membrane of the liposomes and change the size the liposomes particles.
Surface ChargeAnionic
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