Storage | Should always be stored at in the dark at 4 °C, except when brought to room temperature for brief periods prior to animal dosing. DO NOT FREEZE. If the suspension is frozen, the encapsulated drug can be released from the liposomes thus limiting its effectiveness. In addition, the size of the liposomes will also change upon freezing and thawing. |
Appearance | White translucent liquid made of nano size unilamellar liposomes. Usually due to the small size of liposomes no settling will occur in the bottom of the vial. The liposomes are packaged in an amber vial. |
Description | Cationic liposomes are traditionally used for the delivery of genetic materials such as various types of DNA (pDNA, cDNA, CpG DNA, oligonucleotide, antisense oligonucleotide, etc.), various types of RNA such as (siRNA, mRNA, etc.) and nucleic acid mimics (NAMs).The encapsulation of DNA into the conventional neutral charged PC based liposomes can be a technical problem mainly due to the plasmid size. Due to this problem in late 80s, the liposomes composed of cationic lipids and PE have been developed. The idea was to neutralize the negative charge of pDNA with positive charge of cationic lipids…More > |
Lipid composition | DC-Cholesterol/DOPE (1/2 molar ratio) |
Liposome Size | 100 nm |
Buffer | Deionized RNAse-free Water, pH 7.0 |
Shelf-life | 4 months. |
Technical Notes | Liposomes for DNA/RNA Delivery products are formulated using deionized RNAse-free water. N/P ratio means nitrogen to phosphate ratio. N stands for nitrogen and NOT negative. As a matter of fact, nitrogen is positive. P also stands for phosphate and NOT positive. Phosphate carries negative charge. Therefore N/P ratio also stands for positive to negative ratio. Some cationic lipids contain more than one nitrogen, but not all nitrogen atoms carry a positive charge. For example, DC-Cholesterol has two nitrogen atoms and only one of them positive charged. The nitrogen next to the carboxyl group is …More > |
Surface Charge | Cationic |
Product Name | Catalog | Lipid composition | Liposome Size | Price |
---|---|---|---|---|
Clipos™ Cationic DC-Cholesterol Liposomes | CDL5003 | DC-Cholesterol/DOPE (30/70 molar ratio) | 90- 110 nm (by DSL) | $795 |
Clipos™ Cationic DC-Cholesterol Liposomes | CDL5002V | DOTAP/DC-Cholesterol (50/50 molar ratio) | 70-100 nm (by DSL) | $1400 |
Clipos™ Cationic DC-Cholesterol Liposomes | CDEGEN-1713 | DC-Cholesterol/DOPE (1/1 molar ratio) | 100 nm | $1680 |
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