×
Shopping Cart
×
Quote List
0Quotes
0Cart

Clipos™ Cationic DOTAP Liposomes, Lyophilized

Catalog:CDELDP-1295

Unit Size
Price
$2100

Buy Now Need technical support? Datasheet

Specifications QA & Reviews
StorageShould always be stored in a freezer at at -40 °C or -80 °C. Upon adding water to proliposomes, liposomes are formed.
AppearanceWhite lyophilized powder. Liposomes are formed upon adding water to the freeze dried proliposomes and the appearance of the formulation will be white translucent liquid.
DescriptionLiposomes are extensively used to study the interaction of proteins, peptides and other molecules with the surface of a lipid membrane. One of the parameters that affects this interaction is the charge of the liposomal membrane. Liposomes are always made in aqueous environment and they are sized to the desired size in liquid state using various methods such as high pressure extrusion through nano sized pore track etch membranes. Liposome without water is meaningless. In rare occasions, liposomes are freeze dried and proliposomes are formed in the presence of a lyoprotectant such as trehalose. Using a lyoprotectant is necessary in order to maintain the size of the liposomes after rehydration. DOTAP is a cationic lipid and the liposomes made from DOTAP are positively charged. The amount of the positive charge depends on the percentage of the DOTAP in the formulation. The products in Lyophosome?-DOTAP-based catalog use DOPC as a matrix lipid and various amounts of cationic DOTAP lipid from 0.5% to 50% with various zeta potentials. For many different types of experiments and especially the studies that involve the interaction of a protein or peptide with the surface of liposomes, charged liposomes (cationic or anionic) are used. Charged liposomes are also used for many different types of blood complement studies. Cationic liposomes are mainly used for delivery of genetic material.
Lipid compositionDOTAP/DOPC (1/99 molar ratio)
Liposome Size100 nm (after hydration)
BufferLyophilized Phosphate Buffered Saline, 7.4 (after hydration)
Shelf-life6 months.
Technical NotesLiposomes are formed upon hydration of the lyophilized formulation. If the lyophilized liposomes are hydrated with solution containing a water soluble drug then a large percentage of the drug will stay outside of the liposomes and in non-encapsulated form. It is advised to use a micro dialysis cassette or a spin column using the right side beads (depending on the size of your drug) and separate the drug encapsulated liposomes from free drug and perform the drug assay in order to calculate the encapsulation efficiency. Lyophilized liposomes are mainly recommended to be used with drugs that have a short life in aqueous solution mainly due to hydrolysis. After adding the solution of the drug to lyophilized liposomes, the liposomes should be used immediately. Lyophilized Liposomes products should be used by scientists who understand liposome formulation and have the proper equipment in order to check the size, separate the non-encapsulated drug and do the proper assays. Trehalose is used as a lyoprotectant in all freeze dried liposome formulation. The size distribution after hydration of the freeze dried formulation will be around 100 nm.
Surface ChargeCationic
My Review for Clipos™ Cationic DOTAP Liposomes, Lyophilized

Required fields are marked with *

Overall Rating *
×
Related Products
Product Name Catalog Lipid composition Liposome Size Price
Clipos™ Cationic DOTAP Liposomes, Lyophilized CDELDP-1293 DOTAP/DOPC (5/95 molar ratio) 100 nm (after hydration) $2100
Clipos™ Cationic DOTAP Liposomes, Lyophilized CDELDP-1296 DOTAP/DOPC (0.5/99.5 molar ratio) 100 nm (after hydration) $2100
Clipos™ Cationic DOTAP Liposomes, Lyophilized CDL5001V DOTAP/Cholesterol (55/45 molar ratio) 70-90 nm INQUIRY
Clipos™ Cationic DOTAP Liposomes, Lyophilized CDEGEN-1719 DOTAP (100%) 100 nm $1600
Clipos™ Cationic DOTAP Liposomes, Lyophilized CDL5001 DOTAP/DOPE (50/50 molar ratio) 90-110 nm (by DSL) $750
Clipos™ Cationic DOTAP Liposomes, Lyophilized CDELDP-1289 DOTAP/DOPC (40/60 molar ratio) 100 nm (after hydration) $2100
Clipos™ Cationic DOTAP Liposomes, Lyophilized CDEGEN-1721 DOTAP/DOPE (1/1 molar ratio) 100 nm $1680
Clipos™ Cationic DOTAP Liposomes, Lyophilized CDELDP-1290 DOTAP/DOPC (30/70 molar ratio) 100 nm (after hydration) $2100
Products
Fill out the form below
to receive a quote

GET A QUOTE

Services

Drug Targeting Strategy

Drug Delivery Nanoparticles Formulation

Bioparticles Analysis and Characterization

Bioactive Particles & Fillers Production

Functional Biomedical Coatings

Lipid Library Development for Drug Delivery

Aptamer Targeted Drug Delivery System

Other Types of Drug Delivery

Products

Liposome System

Chelating Agents

Bioactive Matrixes

Porous Organic Materials

Biopolymers & Synthetic Polymers

PROTAC

Transfection

Exosome Products

Cleavable Linkers

Pharmaceutical Excipients (drug/medical grade)

Tissue Engineering Scaffold

  • (USA)
  • (Europe)
Cookie Policy | Privacy Policy | Copyright © CD Bioparticles. All rights reserved.
×
Upload products to cart

1. Download the template.

2. Enter product information on the template (maximum number of products: 200).

3. Load the file using selector below.

Drag and drop your file here or

Choose file
*.xlsx (max 20 MB)

4. Click the "Add to cart" button.

×
Upload products to quote list

1. Download the template.

2. Enter product information on the template (maximum number of products: 200).

3. Load the file using selector below.

Drag and drop your file here or

Choose file
*.xlsx (max 20 MB)

4. Click the "Add to quote" button.