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Clipos™ Doxorubicin Encapsulated Liposomes, Biotin lipids, PEGylated

Catalog:CDEIMD-1008

Unit Size
Price
$1980

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Specifications QA & Reviews
Functional GroupBiotin
StorageShould always be stored at in the dark at 4 °C, except when brought to room temperature for brief periods prior to animal dosing. DO NOT FREEZE. If the suspension is frozen, the encapsulated drug can be released from the liposomes thus limiting its effectiveness. In addition, the size of the liposomes will also change upon freezing and thawing.
AppearanceThe product is a red translucent liquid made of nano size unilamellar liposomes. Usually due to the small size of liposomes no settling will occur in the bottom of the vial. The liposomes are packaged in an amber vial.
DescriptionBiotinylated liposomes can be conjugated noncovalently with (strept)avidin through either direct interaction with the protein/antibody conjugated to (strept)avidin or by coupling with other biotinylated proteins using (strept)avidin as a bridging molecule.Both avidin and streptavidin form strong noncovalent bond with biotin. The high resistance to breakdown makes them very useful in bioconjugate chemistry. However, streptavidin has replaced avidin in most bioconjugation applications due to its enhance properties. NeutrAvidin (ThermoFisher) is a modified avidin without negative properties. It performs much better than original avidin and sometimes streptavidin. In order to exploit the high-affinity interaction of biotin with strept(avidin), a two-step “sandwich” protocol (Method A) has been developed for the preparation of targeted immunoliposomes. In this methodology, (strept)avidin is first attached to biotinylated liposomes, then a biotin-modified protein/antibody is introduced into the biotinylated strept(avidin)-labeled liposomes. This noncovalent approach is rapid, extremely versatile and applicable to numerous targeting ligands of interest with respect to in vitro and in vivo applications. Alternatively, instead of forming a strept(avidin) bridge, strept(avidin) molecule can also be covalently conjugated to antibody or ligand (Method B) and non-covalently bound to liposomes containing biotin on surface in order to form immunoliposomes.
Lipid compositionHSPC/Cholesterol/DSPE-PEG(2000)/DSPE-PEG(2000)-Biotin (57/38/4/1 molar ratio)
Liposome Size100 nm
Lipid Molar Concentration21.58 mM
Shelf-life4 months.
Encapsulated DrugDoxorubicin
Lipid Mass Concentration15.61 mg/mL
Drug concentration2 mg/mL (3.45 mM)
Inside BufferAmmonium Sulfate, pH 7.4
Outside BufferPhosphate Buffered Saline, pH 7.4
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