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Clipos™ Doxorubicin Encapsulated Liposomes, Cyanur lipids, PEGylated

Catalog:CDEIMD-1009

Unit Size

2 mL
5 mL

Price: $1980

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Specifications QA & Reviews

Functional Group	Cyanur
Storage	Should always be stored at in the dark at 4 °C, except when brought to room temperature for brief periods prior to animal dosing. DO NOT FREEZE. If the suspension is frozen, the encapsulated drug can be released from the liposomes thus limiting its effectiveness. In addition, the size of the liposomes will also change upon freezing and thawing.
Appearance	The product is a red translucent liquid made of nano size unilamellar liposomes. Usually due to the small size of liposomes no settling will occur in the bottom of the vial. The liposomes are packaged in an amber vial.
Description	Proteins can be covalently coupled to the liposomes via amine-reactive cyanur-groups, either directly to the vesicle surface using cyanuric chloride-activated DSPE (cyanur-DSPE) or to the distal ends of PEG-spacers using activated cyanur-PEG-PE (ammonium salt). Cyanuric chloride at the PEG terminus functions to link peptides, antibodies and other amine-containing biomolecules or nanoparticles via a nucleophilic substitution reaction under basic conditions. Antibodies or other proteins can be conjugated without any previous derivatization.
Lipid composition	HSPC/Cholesterol/DSPE-PEG(2000)/DSPE-PEG(2000)-Cyanur (57/38/4/1 molar ratio)
Liposome Size	100 nm
Lipid Molar Concentration	21.58 mM
Buffer	Borate Buffer, pH 8.8
Shelf-life	4 months.
Encapsulated Drug	Doxorubicin
Lipid Mass Concentration	15.92 mg/mL
Drug concentration	2 mg/mL (3.45 mM)

Related Products

Product Name	Catalog	Lipid composition	Liposome Size	Price
Clipos™ Doxorubicin Encapsulated Liposomes, Cyanur lipids, PEGylated	CDEDOX-1012	HSPC/Cholesterol (60/40 molar ratio)	100 nm	$1200
Clipos™ Doxorubicin Encapsulated Liposomes, Cyanur lipids, PEGylated	CDL3001B-D2	HSPC/Cholesterol/mPEG2000-DSPE (56.2/38.5/5.3 molar ratio)	85 nm (80-90 nm)	$2200
Clipos™ Doxorubicin Encapsulated Liposomes, Cyanur lipids, PEGylated	CDEDOX-1014	HSPC/Cholesterol/DSPE-PEG(2000) (57/38/5 molar ratio)	80-100 nm	$1200
Clipos™ Doxorubicin Encapsulated Liposomes, Cyanur lipids, PEGylated	CDEDOX-1011	HSPC/Cholesterol (60/40 molar ratio)	100 nm	$1380
Clipos™ Doxorubicin Encapsulated Liposomes, Cyanur lipids, PEGylated	CDEIMD-1008	HSPC/Cholesterol/DSPE-PEG(2000)/DSPE-PEG(2000)-Biotin (57/38/4/1 molar ratio)	100 nm	$1980
Clipos™ Doxorubicin Encapsulated Liposomes, Cyanur lipids, PEGylated	CDEIMD-1004	HSPC/Cholesterol/DSPE-PEG(2000)/DSPE-PEG(2000)-DBCO (57/38/4/1 molar ratio)	100 nm	$1980
Clipos™ Doxorubicin Encapsulated Liposomes, Cyanur lipids, PEGylated	CDEIMD-1006	HSPC/Cholesterol/DSPE-PEG(2000)/DSPE-PEG(2000)-Amine (57/38/4/1 molar ratio)	100 nm	$1980
Clipos™ Doxorubicin Encapsulated Liposomes, Cyanur lipids, PEGylated	CDEDOX-1013	HSPC/Cholesterol/DSPE-PEG(2000) (57/38/5 molar ratio)	100 nm	$1380

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