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Clipos™ Doxorubicin Encapsulated Liposomes, Cyanur lipids, PEGylated

Catalog:CDEIMD-1009

Unit Size
Price
$1980

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Specifications QA & Reviews
Functional GroupCyanur
StorageShould always be stored at in the dark at 4 °C, except when brought to room temperature for brief periods prior to animal dosing. DO NOT FREEZE. If the suspension is frozen, the encapsulated drug can be released from the liposomes thus limiting its effectiveness. In addition, the size of the liposomes will also change upon freezing and thawing.
AppearanceThe product is a red translucent liquid made of nano size unilamellar liposomes. Usually due to the small size of liposomes no settling will occur in the bottom of the vial. The liposomes are packaged in an amber vial.
DescriptionProteins can be covalently coupled to the liposomes via amine-reactive cyanur-groups, either directly to the vesicle surface using cyanuric chloride-activated DSPE (cyanur-DSPE) or to the distal ends of PEG-spacers using activated cyanur-PEG-PE (ammonium salt). Cyanuric chloride at the PEG terminus functions to link peptides, antibodies and other amine-containing biomolecules or nanoparticles via a nucleophilic substitution reaction under basic conditions. Antibodies or other proteins can be conjugated without any previous derivatization.
Lipid compositionHSPC/Cholesterol/DSPE-PEG(2000)/DSPE-PEG(2000)-Cyanur (57/38/4/1 molar ratio)
Liposome Size100 nm
Lipid Molar Concentration21.58 mM
BufferBorate Buffer, pH 8.8
Shelf-life4 months.
Encapsulated DrugDoxorubicin
Lipid Mass Concentration15.92 mg/mL
Drug concentration2 mg/mL (3.45 mM)
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