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Clipos™ Doxorubicin Encapsulated Liposomes, Folate lipids, PEGylated

Catalog:CDEIMD-1005

Unit Size
Price
$1980

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Specifications QA & Reviews
Functional GroupFolate
StorageShould always be stored at in the dark at 4 °C, except when brought to room temperature for brief periods prior to animal dosing. DO NOT FREEZE. If the suspension is frozen, the encapsulated drug can be released from the liposomes thus limiting its effectiveness. In addition, the size of the liposomes will also change upon freezing and thawing.
AppearanceThe product is a red translucent liquid made of nano size unilamellar liposomes. Usually due to the small size of liposomes no settling will occur in the bottom of the vial. The liposomes are packaged in an amber vial.
DescriptionFolate binding protein (FBP) is an endogenous protein, which shows a very high affinity for folate. An antibody can be tagged by FBP and an immunoliposome can be formed by non-covalent and high affinity interaction between FBP and folate lipid on the surface of the liposomes. In this method, the antibody, which has been already covalently linked to FBP through a thioether linkage, is conjugated with folate-derivative liposomes. Having a relatively low molecular weight (MW 40 kDa) and a single binding site prevents liposomes from crosslinking.
Lipid compositionHSPC/Cholesterol/DSPE-PEG(2000)/DSPE-PEG(2000)-Folate (57/38/4.5/0.5 molar ratio)
Liposome Size100 nm
Lipid Molar Concentration21.55 mM
Shelf-life4 months.
Encapsulated DrugDoxorubicin
Lipid Mass Concentration15.86 mg/mL
Drug concentration2 mg/mL (3.45 mM)
Inside BufferAmmonium Sulfate, pH 7.4
Outside BufferPhosphate Buffered Saline, pH 7.4
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