×
Shopping Cart
×
Quote List
0Quotes
0Cart

Clipos™ Doxorubicin Encapsulated Liposomes, Succinyl lipids, PEGylated

Catalog:CDEIMD-1015

Unit Size
Price
$1980

Buy Now Need technical support? Datasheet

Specifications QA & Reviews
Functional GroupSuccinyl
StorageShould always be stored at in the dark at 4 °C, except when brought to room temperature for brief periods prior to animal dosing. DO NOT FREEZE. If the suspension is frozen, the encapsulated drug can be released from the liposomes thus limiting its effectiveness. In addition, the size of the liposomes will also change upon freezing and thawing.
AppearanceThe product is a red translucent liquid made of nano size unilamellar liposomes. Usually due to the small size of liposomes no settling will occur in the bottom of the vial. The liposomes are packaged in an amber vial.
DescriptionNumerous techniques have been developed to prepare immunoliposomes based on the nucleophilic reactivity of free amine groups of proteins or peptides. One of the most popular and commonly used methods is to covalently couple free carboxylic groups to primary amines through activation of the carboxyl groups with EDC (1-ethyl-3-[3-dimethylaminopropyl] carbodiimide). EDC, which is a so-called zero-length crosslinking agent, reacts with the carboxyl to form an amine reactive intermediate (O-acylisourea). The produced O-acylisourea can be easily displaced by nucleophilic attack from primary amino groups in the reaction mixture. However, this intermediate is unstable and hydrolyzed in aqueous solutions. In order to prevent the intermediate hydrolysis, sulfo-NHS (N-hydroxysulfosuccinimide) is added to EDC to produce a significantly more stable and more soluble active intermediate (NHS ester). Consequently, the immunoliposomes are prepared by a two-step coupling procedure: first, activating the free carboxyl group of the linker lipid incorporated in the liposomes with EDC and sulfo-NHS, and then covalently conjugating antibodies to the lipids through displacement of sulfo-NHS groups by antibody amines, as depicted below. EDC/sulfo-NHS coupling reactions are highly selective and highly efficient, and the biological activity of the protein or peptide is preserved.
Lipid compositionHSPC/Cholesterol/DSPE-PEG(2000)/DSPE-PEG(2000)-Succinyl (57/38/4/1 molar ratio)
Liposome Size100 nm
Lipid Molar Concentration21.58 mM
BufferPhosphate Buffered Saline, pH 6
Shelf-life4 months.
Encapsulated DrugDoxorubicin
Lipid Mass Concentration15.91 mg/mL
Drug concentration2 mg/mL (3.45 mM)
My Review for Clipos™ Doxorubicin Encapsulated Liposomes, Succinyl lipids, PEGylated

Required fields are marked with *

Overall Rating *
×
Related Products
Product Name Catalog Lipid composition Liposome Size Price
Clipos™ Doxorubicin Encapsulated Liposomes, Succinyl lipids, PEGylated CDEIMD-1005 HSPC/Cholesterol/DSPE-PEG(2000)/DSPE-PEG(2000)-Folate (57/38/4.5/0.5 molar ratio) 100 nm $1980
Clipos™ Doxorubicin Encapsulated Liposomes, Succinyl lipids, PEGylated CDEIMD-1006 HSPC/Cholesterol/DSPE-PEG(2000)/DSPE-PEG(2000)-Amine (57/38/4/1 molar ratio) 100 nm $1980
Clipos™ Doxorubicin Encapsulated Liposomes, Succinyl lipids, PEGylated CDEIMD-1004 HSPC/Cholesterol/DSPE-PEG(2000)/DSPE-PEG(2000)-DBCO (57/38/4/1 molar ratio) 100 nm $1980
Clipos™ Doxorubicin Encapsulated Liposomes, Succinyl lipids, PEGylated CDL3001B-D2 HSPC/Cholesterol/mPEG2000-DSPE (56.2/38.5/5.3 molar ratio) 85 nm (80-90 nm) $2200
Clipos™ Doxorubicin Encapsulated Liposomes, Succinyl lipids, PEGylated CDEDOX-1011 HSPC/Cholesterol (60/40 molar ratio) 100 nm $1380
Clipos™ Doxorubicin Encapsulated Liposomes, Succinyl lipids, PEGylated CDEIMD-1008 HSPC/Cholesterol/DSPE-PEG(2000)/DSPE-PEG(2000)-Biotin (57/38/4/1 molar ratio) 100 nm $1980
Clipos™ Doxorubicin Encapsulated Liposomes, Succinyl lipids, PEGylated CDEDOX-1014 HSPC/Cholesterol/DSPE-PEG(2000) (57/38/5 molar ratio) 80-100 nm $1200
Clipos™ Doxorubicin Encapsulated Liposomes, Succinyl lipids, PEGylated CDEIMD-1003 Cholesterol/DSPE-PEG(2000)/DSPE-PEG(2000)-PDP (57/38/4 molar ratio) 100 nm $1980
Products
Fill out the form below
to receive a quote

GET A QUOTE

Services

Drug Targeting Strategy

Drug Delivery Nanoparticles Formulation

Bioparticles Analysis and Characterization

Bioactive Particles & Fillers Production

Functional Biomedical Coatings

Lipid Library Development for Drug Delivery

Aptamer Targeted Drug Delivery System

Other Types of Drug Delivery

Products

Liposome System

Chelating Agents

Bioactive Matrixes

Porous Organic Materials

Biopolymers & Synthetic Polymers

PROTAC

Transfection

Exosome Products

Cleavable Linkers

Pharmaceutical Excipients (drug/medical grade)

Tissue Engineering Scaffold

  • (USA)
  • (Europe)
Cookie Policy | Privacy Policy | Copyright © CD Bioparticles. All rights reserved.
×
Upload products to cart

1. Download the template.

2. Enter product information on the template (maximum number of products: 200).

3. Load the file using selector below.

Drag and drop your file here or

Choose file
*.xlsx (max 20 MB)

4. Click the "Add to cart" button.

×
Upload products to quote list

1. Download the template.

2. Enter product information on the template (maximum number of products: 200).

3. Load the file using selector below.

Drag and drop your file here or

Choose file
*.xlsx (max 20 MB)

4. Click the "Add to quote" button.