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Clipos™ Cardiolipin Lipids (CL) Liposomes

Catalog:CDECAR-1645

Unit Size
Price
$2100

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Specifications QA & Reviews
StorageShould always be stored at in the dark at 4 °C, except when brought to room temperature for brief periods prior to animal dosing. DO NOT FREEZE. If the suspension is frozen, the encapsulated drug can be released from the liposomes thus limiting its effectiveness. In addition, that the size of the liposomes will also change upon freezing and thawing.
AppearanceWhite translucent liquid made of nano size unilamellar liposomes. Usually due to the small size of liposomes no settling will occur in the bottom of the vial. The liposomes are packaged in an amber vial.
DescriptionCardiolipin (CL) is a unique phospholipid with a very interesting chemical and specific ultrastructural characteristics. It is a highly acid dimer of phosphatidylglycerol (PG) and phosphatidic acid (PA), containing four acyl chains; three glycerols and two phosphate headgroups. Due to deprotonation of one of one of these phosphate groups, cardiolipin is negatively charged in physiological pH. Cardiolipin (CL) is known as mitochondria-specific phospholipid since it is almost exclusively biosynthesized and located in the inner mitochondrial membranes. The name “cardiolipin” is derived from fact that it was first found and isolated from animal heart. Cardiolipin is considered to be be intimately linked to mitochondrial bioenergetic process. It plays a functional role in mitochondrial membrane stability and dynamics, interacts with a number of inner mitochondrial membrane metabolite carriers, enzymes and proteins. During apoptosis in presence of H2O2, CL-bound Cyt c catalyzes the peroxidation of cardiolipin, releasing Cyt c, which is a death-inducing protein. The structure of 18:1 cardiolipin molecule with an anionic headgroup. The fatty acid tail contains 18 carbon atoms and one unsaturated double bond. The structure of 14:0 cardiolipin molecule with an anionic headgroup. The fatty acid tail is fully saturated and contains 14 carbon atoms and zero unsaturated double bond.
Lipid compositionPC/CL (0.5/99.5 molar ratio)
Liposome Size100 nm
Lipid Molar Concentration10 mM
BufferPhosphate Buffered Saline, pH 7.4
Shelf-life4 months.
Technical NotesLiposomes are unilamellar and sized to 100 nm. If you need them to be made in another size then you should mention that at the time of ordering. Unilamellar liposomes can be made in 50 nm and 200 nm sizes. Liposomes that are larger than 200 nm are multilamellar structure. Liposomes are made in PBS buffer at pH 7.4 but it can be made in any other buffer of your choice. You can specify your buffer at the time of ordering. Liposomes are made in degassed buffer that is purged with argon to avoid oxidation of the unsaturated phospholipids. Liposomes are made under sterile condition. Liposomes are unilamellar and therefore due to their small size they will not settle in the bottom of the vial. If you need to take multiple aliquots out of the vial during a period of time, then it is advised to take extreme care in not contaminating the vial. It is recommended to handle the vial under a sterile hood to maintain the sterility of the product. Liposomes should never be frozen. Crystal ice that is formed during freezing will rupture the lipid membrane of the liposomes and change the size the liposomes particles.
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