Stability Improvement

• Passive Drug Targeting by New Coatings and Modification Techniques
• Passive Drug Targeting by Modifying Particle Size, Shape and Surface Characteristics

CD Bioparticles’ services with customized delivery strategies, precise designs and modifications of drugs or drug-contained cargos, and advanced technical platforms can help you to solve:

The challenges you might meet:

• Fast clearance/ fast degradation/ short circulation time of the drugs
• Unwanted immunogenicity
• Bad dispersion of the drugs
• The requirements for further processing the drugs, such as dispersing in, blending in or coating on another phase

Key Stability Improvement Features

• Process of size and structure re-construction discovery

• Chemical and biological protection discovery

  • Hydrophobic modification of drugs

  • Hydrolyzable modification of drugs

  • Enzyme inhibitors modifications

  • Cell-membrane coating

• Physical encapsulation discovery

  • Liposome encapsulation

  • Polymer cargo encapsulation

  • Endosome-escape cargo discovery

• PEGylation discovery

Key Stability Improvement Benefits:

• The process of size and structure re-construction of the drugs can prolong the circulation time of the drugs
• Hydrophobic modification of the polar, small drug molecules improves the cell permeability during the passive delivery
• Hydrolyzable pro-drug prolongs the degradation time to increase the circulation time of the drugs
• Enzyme inhibitors modifications inhibits the degradation of the drugs or drug-contained cargos from some specific enzymes
• Specific cell-membrane coating of the drugs or drug-contained cargo can decrease the clearance by the immune-cells
• Liposome and polymer-based micelles and polyersomes provide physical protection shell of the encapsulated drugs
• Liposome and polymer-based micelles and polyersomes provide the options of customized modifications for active-targeting delivery and controlled-release delivery
• Physical encapsulation systems improve the dispersion and size-regulation of the hardly dissolved drugs
• Physical encapsulation systems provide the opportunities for the further processing, such as coating and blending, and prevents the degradation of the drugs during processing
• Endosome-escape cargo increases the viability of the drugs in the endosomes
• Optimized PEGylation density improves the retention of the drugs but not preventing the clearance the drugs and the drug-target interactions

Stability Improvement Application Candidates:

• Small drug molecules but with high polarity
• Small drug molecules but easy-to-degrade
• Hardly dissolved, hardly dispersed, crystalized drugs
• Oral-delivery or intravenous-delivery drugs
• The drugs needed to be further processed, such as dispersion, coating or blending in a new phase