Poly(ethylene glycol)

Poly(ethylene glycol) (PEG) has emerged as a pivotal player in the realm of drug delivery, revolutionizing therapeutic approaches. This versatile polymer, composed of repeating ethylene glycol units, exhibits unique properties that make it an ideal candidate for enhancing drug efficacy. PEG's hydrophilic nature imparts water solubility to poorly soluble drugs, facilitating their administration. Moreover, its biocompatibility and resistance to protein adsorption reduce immunogenicity and enhance drug circulation time in the bloodstream. PEGylation, the process of attaching PEG chains to drug molecules, provides a stealth effect, preventing rapid clearance by the immune system and optimizing bioavailability. Additionally, PEG serves as a scaffold for the design of various drug delivery systems, such as nanoparticles and micelles, allowing targeted and controlled release of therapeutic agents.